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Articles by N.S.H.N. Moorthy
Total Records ( 3 ) for N.S.H.N. Moorthy
  N.S.H.N. Moorthy and P. Trivedi
  In pursuit of effective anticancer molecules that can overcome resistance problems, a series of cytotoxic N10 substituted 2-methoxy acridone analogues were subjected to quantitative structure activity relationship analysis employing 2D molecular descriptors calculated from QSAR software Dragon. Multiple linear regression analysis of the data following a stepwise technique resulted in statistically significant triparametric models with good predictive power (r>0.9, q2>0.8). The results of the study suggest that flexibility of substituent sidechain and four membered methylene bridges between the acridone nucleus and substituents enhances the cytotoxic potency of 2 methoxy acridones. Further, the generated QSAR models also indicate that bulky substituents and the presence of sulfur atoms are disfavored whereas heteroatoms in the molecular extremity are favored for cytotoxic activity.
  C.M. Lucksha , D. Agarwal , N.S.H.N. Moorthy , C. Karthikeyan and P. Trivedi
  Synthesis and biological evaluation of amino acid conjugates of cinmetacin was carried out to improve some pharmacokinetic properties and to minimize some undesirable side effects (especially ulcerogenic effect). Dissolution studies and hydrolysis studies on simulated intestinal fluid (pH 7.4) follow the first order kinetics. The quantitative structure property relationship studies reveals that rate of hydrolysis of the compounds is inversely related to partition coefficient values. The study of acute and chronic anti-inflammatory and ulcerogenic activity gave statistically significant results and it concluded that the compounds minimize the gastric side effects of cinmetacin remarkably.
  C. Karthikeyan , S. Siva kumar , P. Chandrasekar , A. Heber , S.J.H. Robert and N.S.H.N. Moorthy
  Antisecretory, gastric transit time and wound healing activity of various extract of the shade-dried powder of Asclepias daemia leaves was studied in albino rat and mice respectively. Concentration of gastric hydrogen ions was determined for antisecretory activity by titration with 0.01 N sodium hydroxide using Tofer’s reagent as an indicator. The gastric transit activity was determined by using charcoal meal. The results showed that chloroform and aqueous extract produced significant action on antisecretory, gastric transit time and wound healing activities, while petroleum ether extract have no remarkable activity. Aqueous extract showed highly significant (p<0.01) antisecretory and gastric transit activities.
 
 
 
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