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Articles by N.O. Al-Harbi
Total Records ( 1 ) for N.O. Al-Harbi
  N.O. Al-Harbi
  Background: Liver fibrosis is the principle feature of injury caused by chronic liver disease leading to clinical death. Schistosomiasis causes pathology in 200 million individuals worldwide. The perisinusoidal stellate cells of the liver in an injury milieu undergo activation, acquiring a myofibroblast-like phenotype. In this state, they are the principle source of collagen and related proteins in fibrosis. Aim: The present studies evaluate in vitro, the mechanism of action of an antifibrotic compound Safironil, which was designed as competitive inhibitor of collagen protein synthesis. Results: In vivo, the studies investigate its possible effect on reversal of liver fibrosis by combination with Praziquantel in mice. in vitro, safironil prevented fibromyoblast activation monitored by the level of collagen I mRNA or smooth muscle α-actin and fibrogenesis judged by collagen type I and III and laminin production. In animals, Safironil had no effect on liver granulomas sizes without altering total hydroxyproline but alter the pattern of fibrosis by increasing type III and decreasing type I collagen deposition. When Safironil was combined with Praziquantel, best results were attained. The mechanism is probably through stop of new liver insult and interruption of collagen type I synthesis with attenuation of pre-existent collagen. Conclusion: Although, these results are promising in experimental schistosomiasis, further studies are required to study its possible application in humans.
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