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Articles by N.H. Othman
Total Records ( 2 ) for N.H. Othman
  H.B. Sahib , A.F. Aisha , M.F. Yam , M.Z. Asmawi , Z. Ismail , S.M. Salhimi , N.H. Othman and A.M.S. Abdul Majid
  Angiogenesis is a process by which new blood vessels are formed from the pre-existing blood vessel. Orthosiphon stamineus Benth. OS has been used as a medicinal herb for many centuries. Due to the presence of high level of anti-oxidants and phenolic content compounds in OS and the effect of anti-oxidants and phenolic compounds being anti-angiogenic, the perturbation of new blood vessels ability of OS was tested. Dry powdered leaves of the OS plant were extracted with Petroleum Ether (PE), chloroform (CE), methanol (ME) and water (WE) by using sequential cold maceration method. The ME of OS has the highest anti-angiogenic activity (93.28±1.24%) in the rat aortic assay followed by CE (85.55±1.64%), PE (51.54±4.12%) and WE (50.22±1.23%) in descending order of reactivity. The methanol extract was also found to have potent anti-oxidant activity in the1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. The IC50 value was measured to be 0.286 mg mL-1. The total phenolic content of 1 mg mL-1 of methanol extract was equal to 38.27%.
  H.B. Sahib , Z. Ismail , N.H. Othman and A.M.S. Abdul Majid
  Estrogen Receptor (ER+) antagonist, Tamoxifen (TMX), is widely used in the treatment of the hormone responsive breast cancer. However, the common occurrence of resistance after prolonged treatment of TMX hampers its effectiveness. Orthosiphon stamineus Benth. (OS) is a common herb found in South East Asia and is used traditionally to treat various types of ailments. The aim of this study was to determine whether the methanolic extract of Orthosiphon stamineus Benth. (MEOS), that had been proven in previous study to act as anti-angiogenic agents, enhance the anticancer efficacy of ER+ antagonists. In this study methanolic extract of (MEOS) was treated to MCF-7 hormone sensitive breast cancer cell line with the addition of TMX. MEOS showed no significant cytotoxic effect towards MCF-7 when used alone, however when combined with TMX, the anti proliferative activity of the combination increased five fold higher when compared to the anti-proliferative activity of singly treated TMX. The result suggests that MEOS synergistically enhance the activity of TMX against hormone responsive breast cancer cells in vitro and may prove to be useful for the treatment of metastatic breast cancer.
 
 
 
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