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Articles by N.H. Ismail
Total Records ( 2 ) for N.H. Ismail
  R. Ahmad , H.M. Hashim , Z.M. Noor , N.H. Ismail , F. Salim , N.H. Lajis and K. Shaari
  The aim of the study was to evaluate the antioxidant and antidiabetic potential of five Malaysian Uncaria species namely U. lucida, U. acida, U. cordata, U. callophylla and U. longiflora var. pteropoda, find any correlation between these two activities and relate them to their phytochemical content. Measurement of antioxidant activities employed ferric thiocyanate (FTC), thiobarbituric (TBA) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays while evaluation of total phenolic contents employed Folin Ciocalteau methods. Antidiabetic potential was evaluated by α-glucosidase inhibitory assays. All tested extracts exhibited very strong antioxidant potential in the FTC and TBA assays. U. longiflora v.p. (stems and leaves) and U. calophylla (stems) exhibited strong DPPH free radical scavenging activity with IC50 values of 8-20 μg mL-1 compared to 8 μg mL-1 for vitamin C and 7 μg mL-1 BHT. In the α-glucosidase inhibitory assay, the stem extracts of the two plants showed strong α-glucosidase inhibition (>99%). The anti-diabetic activity exhibited by the two plants correlated well with its radical scavenging activities and its phytochemical content. This study has found Malaysian Uncaria to be potentially important sources of antioxidants and anti-diabetic agents, which may be used in prevention and control of type II diabetes.
  N.A. Ghani , N. Ahmat , N.H. Ismail , I. Zakaria and N.K.N.A. Zawawi
  Phytochemical investigation of the stem bark of Polyalthia cauliflora var. cauliflora has led to the isolation of two chalcones and an alkaloid; 2’, 4’-dihydroxy-3’-methoxychalcone (1), 2’, 4’-dihydroxychalcone (2) and liriodenine (3). 2’, 4’-dihydroxy-3’-methoxychalcone (1) n was found to be cytotoxic against HL-60, MCF-7 and HeLa cancer cell lines with IC50 value of 12.2, 5.1 and 12.5 μg mL-1, respectively. 2’, 4’-dihydroxy-3’-methoxychalcone may prove to be useful in cancer treatment and prevention. The aims of this study were to extract, fractionate and isolate the chemical constituents from the stem bark of Polyalthia cauliflora var. cauliflora. Various chromatographic techniques including glass column chromatography, preparative thin layer chromatography and centrifugal chromatography had been used in this study. The isolated compounds were elucidated using several spectroscopic techniques including 1H and 13C NMR, IR, UV-Vis, mass spectroscopy and comparison with literature. Potential and sufficient amount of compounds were subjected to cytotoxic activity against HL-60, MCF-7 and HeLa cancer cell lines.
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