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Articles by N.B. Isong
Total Records ( 1 ) for N.B. Isong
  Henry D. Akpan , Itemobong S. Ekaidem , Itoro F. Usoh , Patrick E. Ebong and N.B. Isong
  Aim: The effects of aqueous extract of Azadirachta indica on blood glucose concentration, serum α-amylase activity, body weight and pancreatic integrity of normal and alloxan-induced diabetic Wistar rats were investigated with the view to establishing possible mechanism of its antidiabetic action. Method: Thirty-two Wistar rats were randomly divided into four groups (1-4) of 8 rats each. Groups 1 and 2 rats were made diabetic by intraperitoneal administration of 150 mg kg-1 alloxan monohydrate while groups 3 and 4 were normal rats. Groups 2 and 4 were treated with 400 mg kg-1 of aqueous extract of Azadirachta-indica leaves. Groups 1 and 3 rats were treated with placebo (0.5 mL distilled water). Treatments were administered to the rats by oral intubations for a period of 14 days and animals were maintained on commercial rat chow and tap water ad libitum. Results: Results showed that treatment with the extract caused a significant (p<0.05) reduction in fasting blood glucose level in the extract treated Diabetic (DT) rats by 54% but not in the extract treated Normal (NT) rats. The serum α-amylase activity was also significantly lower (p<0.05) in the extract treated Diabetic rats (DT) when compared to the placebo treated Diabetic Control (DC). However, there was no significant difference (p<0.05) in the serum α-amylase activity of the Normal Treated (NT) rats when compared to the normal control. Histological examination of pancreas of diabetic control rats showed cellular degeneration which appeared to be reversed in the animals following extract treatment. Conclusion: We concluded that the extract might have antidiabetic properties, which may be associated with enhanced islets cells regeneration.
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