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Articles by N.A. Khan
Total Records ( 2 ) for N.A. Khan
  N.A. Khan , P. Chattopadhyay , A. Pawdey , K. Kishore and A.K. Wahi
  Oxidative stress plays a major role in the etiopathology of myocardial Ischemic Reperfusion (IR) injury which is a common sequel of ischemic heart disease. Antioxidants have potent therapeutic effects on both ischemic heart disease and ischemic-reperfusion injury. In the present study, the effect of co-enzyme Q10 (CoQ10) on oxidative stress associated with IR injury was investigated in a rat heart model. Eighteen rats of 200-250 g b.wt. were divided into sham-operated control group (I) (n = 6), ischemia and reperfusion group (II) (n = 6) and CoQ10 (1 mg kg-1 b.wt. daily by oral route for 7 days before induced ischemia reperfusion) treated group (III) (n = 6) used for induction of ischemia-reperfusion injury. Hearts from all the groups were then processed for biochemical and histopathological studies. All values were expressed as mean±SD. Differences in mean values were compared using SPSS 11.0 by one-way ANOVA and Student-Newman-Keul (SNK) test. A value of p<0.05 was considered statistically significant. There was a significant increase in myocardial catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities of these enzymes in mitochondria were maintained to near normal (p<0.05) level in CoQ10 treated groups with significant change in group (III) group when compared to group (II). Ischemia and reperfusion induced toxicity reduced remarkable amount of RNA content as compared to sham operated control rat. CoQ10 attenuated decrease DNA and RNA content induced by ischemic and reperfusion. Histopathology studies showed degree of myocardial damage in CoQ10 administered group showing normal structure of myocytes with mild edema during the cardiac IR, which reached a level comparable to sham operated rats. The study strongly suggests that CoQ10 administration prevents oxidative stress and associated ultrastructural changes, induced by myocardial ischemic-reperfusion injury.
  N.A. Khan , S. Ghosh and S.P. Ghosal
  This study presents a new and efficient approach for capacitor placement in radial distribution systems with an objective of improving the voltage profile and reduction of power loss. In this study, optimal distributed generation allocation for loss reduction in distribution network. The main purpose of this study is to discuss the basic understanding of power quality in relation to the distributed generation. A Canonical Complementary Particle Swarm Optimization Algorithm (CCPSOA) was used as solving tool. This algorithm is used to minimize an objective function. For applying CCPSOA, software is programmed under Matlab software is prepared. This proposed CPSO method is implemented on IEEE 30 and IEEE 69-bus systems and the results may show that the proposed method is better than the other methods. The results prove the efficiency of the proposed method.
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