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Articles by N. Subramanian
Total Records ( 3 ) for N. Subramanian
  C. Jothimanivannan , R.S. Kumar and N. Subramanian
  The aim of the present study was to evaluate the anti-inflammatory and analgesic activities of the ethanol extract of aerial parts of Justicia gendarussa (EJG) in animal models. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced rat paw edema and cotton pellet granuloma method. The analgesic activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy’s hot plate method and acetic acid-induced writhing, respectively. The study was carried out in two different dose levels of 250 and 500 mg kg-1 orally. The EJG did not produce any mortality up to 2000 mg kg-1. EJG at the dose of 500 mg kg-1 showed maximum inhibition of 52% in carrageenan-induced paw edema and 45% inhibition in dry weight cotton pellet granuloma formation. Dose dependent increase in latency of response in the hot plate method and 33% inhibition in acetic acid induced writhings in mice were observed with EJG at the dose of 500 mg kg-1. The pharmacological screening of the extract showed significant (p<0.001-0.01) dose-dependent anti-inflammatory activity with good analgesic profile when compared with reference standard. The presence of flavonoids might be responsible for these activities and which are probably mediated via inhibition of various autocoids formation and release.
  R. Bindu and N. Subramanian
  Results of room temperature photoluminescence studies carried out on undoped (pristine) single-phase BaFBr compound, prepared in air by laser heating are presented. On irradiation using 266 nm, we find an intense and broad emission band peaking at 466 nm and another relatively narrow band at 313 nm. The former band is indicative of presence of stable centres while the latter is a signature of stable VK(Br2) centres in the matrix. The unusual and new observation of strong luminescence from both types of centres at room temperature has been interpreted as possibly be due to their stabilization by various defect entities in the BaFBr matrix formed on account of the non-equilibrium manner in which the sample has been prepared by the novel laser-heating technique. An interesting oscillatory temporal behaviour of the 466 nm peak intensity upon constant UV irradiation at 266 nm is also reported.
  N. Subramanian , C. Jothimanivannan , R. Senthil Kumar and S. Kameshwaran
  Background: Anxiety is associated with diverse range of psychiatric conditions. Justicia gendarussa Burm. (Acanthaceae) has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago and chorea. Despite a long tradition of use, no systematic phytochemical and pharmacological work has been carried out on this potential plant. Objective: Thus, Justicia gendarussa Burm was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. Materials and method: In the present investigation the aerial parts of plant parts were extracted with ethanol. The plant extract (EJG) at the dose of 250 and 500 mg kg-1 were evaluated for anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. EJG administered orally in two different doses of 250 and 500 mg kg-1, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze, also increases the time spent by mice in the illuminated side of the light-dark test, as well as caused significant reduction in freezing time in comparison with control animals. This effect was comparable to that of the benzodiazepine diazepam at the dose of 2.0 mg kg-1. Conclusion: These results indicate that ethanolic extract of Justicia gendarussa Burm has an effective anti-anxiety effect.
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