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Articles by N. Subhashini
Total Records ( 2 ) for N. Subhashini
  N. Subhashini , G. Nagarajan and S. Kavimani
  Trigonella foenum graecum (Leguminosae) (Eng: fenugreek, Tamil: Vendayam) is a well known spicy agent and seeds are used traditionally for several medicinal purposes. In present study the ethanol extract of seeds from Trigonella foenum graecum (EETFG) was evaluated for its anti- inflammatory activity in acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced granuloma). In all models the EETFG (75 and 150 mg kg-1 b.wt. p.o.) exhibited significant anti-inflammatory activity (p<0.001) in a dose dependent manner when compared with saline control. Indomethacin (10 mg kg-1 b.wt. p.o.) was used as reference drug. The EETFG was evaluated for its antioxidant properties by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and in vitro lipid peroxidation induced by the Fe2+-ascorbate system in rat liver homogenate. In DPPH radical scavenging assay, the EETFG demonstrated marked and dose dependent free radical scavenging effect and the mean inhibitory concentration (IC50) of the EETFG was found to be 75.2 μg mL-1 while the ascorbic acid (reference) exhibited 43.7 μg mL-1. The EETFG effectively inhibited the lipid peroxidation in a dose related manner showing the IC50 value of 279.1 μg mL-1, whereas the quercetin (reference) showed 46.6 μg mL-1. These findings revealed that the Trigonella foenum graecum seeds had remarkable acute and chronic anti-inflammatory and in vitro antioxidant actions in the tested models validating its traditional uses.
  K. AsokKumar , M. UmaMaheswari , A.T. Sivashanmugam , V. SubhadraDevi , N. Subhashini and T.K. Ravi
  Glinus oppositifolius (L.) Aug. DC. (Aizoceae), commonly called slender carpet weed, is a prostrate or diffuse herb which acts as stomachic, uterine stimulant, aperient and lochia. It is used traditionally in the treatment of earache, itch and skin diseases. Glinus oppositifolius was extracted with ethanol (70%) and used for the evaluation of various in vitro antioxidant assays which includes H-donor activity, nitric oxide scavenging, superoxide anion scavenging, reducing ability, hydroxyl radical, hydrogen peroxide scavenging, total phenolic content, total flavonoid content, total antioxidant activity by thiocyanate and phosphomolybdenum method, metal chelating, β-carotene bleaching, total peroxy radical assays. The pro-oxidant activity was measured using bleomycin-dependent DNA damage. Ex vivo models such as lipid peroxidation were used to study the antioxidant property of the extract. The various antioxidant activities were compared with suitable standard antioxidants such as ascorbic acid, butylated hydroxyl toluene (BHT), α-tocopherol, curcumin, quercetin and Trolox. The generation of free radicals, viz., O2·, OH·, H2O2, NO· and peroxyl radicals, were effectively scavenged by the ethanol extract of Glinus oppositifolius. The antioxidant activity depends on concentration and increases with increasing amounts of the extract. The total phenolic content, flavonoid content and total antioxidant activity in Glinus oppositifolius were determined as microgram (μg) pyrocatechol, quercetin and α-tocopherol equivalent/mg, respectively. The extract did not exhibit any pro-oxidant activity when compared with ascorbic acid. The results obtained in this study indicate that Glinus oppositifolius scavenges free radicals and reduces lipid peroxidation, ameliorating the damage imposed by oxidative stress in different disease conditions and serve as a potential source of natural antioxidant.

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