Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by N. Ramesh
Total Records ( 5 ) for N. Ramesh
  V. Rajesh Kannan , G. Stalin Rajasekar , P. Rajesh , V. Balasubramanian , N. Ramesh , E. King Solomon , D. Nivas and S. Chandru
  The present study intended to evaluate the beneficiary effects of ethanolic extract of Terminalia chebula Retz. fruits (EETC) by using alloxan-monohydrate induced diabetic control by using Wistar Albino rats. The toxicity study was performed on aliquot doses of EETC (100 to 500 mg kg-1 b.wt.) and predetermined the LD50 value on 30 days evaluation; also the behavioral changes, symptoms and mortality have been checked, the EETC showed the nil toxicity up to 500 mg kg-1 b.wt. The effect of EETC (200 mg kg-1 b.wt.) was compared with the glibenclamide (600 mg kg-1 b.wt.) that is often used as a standard drug and the anti-diabetic activity has been conducted for 30 days. After the completion of the study, animals were dissected through cervical dislocation and collected the blood, serum and pancreas. The collected samples were performed under parameters like biochemical and anti-oxidant enzymes related to diabetes such as, weight variation, blood glucose, plasma insulin, serum and liver protein, serum and liver cholesterol, serum and liver triglyceride, serum and liver phospholipids, SGOT (Serum Glutamate Oxaloacetic Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase), ACP (Acid Phosphatase), ALP (Alkaline Phosphatase), GSH (Glutathione reductase), GPT (Glutamate Pyruvate Transaminase), GPX (Glutathione Peroxidase) ,CAT (Catalase) and histopathological sections of the pancreas, the above parameters calculated and showed that the significance at p<0.001 to 0.05. The histopathological changes caused after induction of alloxan showed the granular cytoplasm, dilatation, shrunken nuclei and inflammation, which were reduced after treatment of the EETC (200 mg kg-1 b.wt.). Excess proliferation of epithelium in the pancreas was observed in diabetic rats, which was reduced after administration of the EETC (200 mg kg-1 b.wt.). From the evaluation of the present study on EETC has been confirmed that having the pharmacological action against the diabetic condition, even though the mechanism of the action is unknown, also it can be used further molecular compound analysis and define the chemical to the action.
  R. Mahalakshmi , P. Rajesh , N. Ramesh , V. Balasubramanian and V. Rajesh Kannan
  The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. The V. negundo Linn. is a natural plant product, in it’s the leaves are used with the added advantage to revert Ibuprofen induced hepatotoxicity. Oral administration of ethanol extract of V. negundo (100 and 300 mg) produced a significant and dose dependent inhibition to the acute hepatotoxic induced rats and various parameters were analyzed, when compared with negative control V. negundo showed that the significant activity in 300 mg/kg/b.wt. They exhibited a significant inhibition of hepatic toxicity by using various marker enzymes and the histopathological analysis. The inhibitory effect of the V. negundo on hepatotoxicity was compared to that of positive control group. The various parameters such glucose, protein, triglycerides, bilirubin, urea, creatinine, ALP, ACP, SGPT, SGOT and histopathological parameters was measured by dissection the rats. A significant index and values were observed in the acute assays; an effective significant alteration in all biochemical and histopathological sections was observed. From these results, concluded that the V. negundo having the potential effectiveness at the dose of 300 mg/kg/b.wt., (p<0.01) significance in a dose dependent manner. These results suggest that leaves of V. negundo having the hepatoprotective activity, which support the hepatic cells protection.
  Socorrina Colaco , N. Ramesh , Sekar Rajan and Subramania Nainar Meyyanathan
  Objective was to compare pharmacokinetic characteristics of Sustained-Release (SR) and Immediate-Release (IR) formulations of dextromethorphan hydrobromide following a single oral administration of test and reference formulations in fasting healthy male volunteers. A randomized, 3-way, crossover, bioequivalence study was conducted in 6 healthy male volunteers to compare dextromethorphan hydrobromide Sustained Release (SR) tablet as test and the Immediate Release (IR) as reference product. Blood samples were collected and plasma samples were determined by using validated HPLC method involving a solid phase extraction method. Pharmacokinetic parameters were calculated by non-compartmental analysis. Cmax of the sustained-release formulation was significantly lower than that of the marketed immediate-release. The Tmax of sustained-release formulation was significantly long-lasting than that of immediate release. These results are in line with the profile of a sustained-release drug. This was also evident by the lower elimination rate and higher t½ values. However, the bioavailability of sustained-release tablets remained the identical as that of immediate release tablets.
  Sekar Rajan , Socorrina Colaco , N. Ramesh , Subramania Nainar Meyyanathan and K. Elango
  This study describes the development and validation of dissolution tests for sustained release Dextromethorphan hydrobromide tablets using an HPLC method. Chromatographic separation was achieved on a C18 column utilizing 0.5% triethylamine (pH 7.5) and acetonitrile in the ratio of 50:50. The detection wavelength was 280 nm. The method was validated and response was found to be linear in the drug concentration range of 10-80 μg mL-1. The suitable conditions were clearly decided after testing sink conditions, dissolution medium and agitation intensity. The most excellent dissolution conditions tested, for the Dextromethorphan hydrobromide was applied to appraise the dissolution profiles. The method was validated and response was found to be linear in the drug concentration range of 10-80 μg mL-1. The method was established to have sufficient intermediate precision as similar separation was achieved on another instrument handled by different operators. Mean Recovery was 101.82%. Intra precisions for three different concentrations were 1.23, 1.10 0.72 and 1.57, 1.69, 0.95 and inter run precisions were % RSD 0.83, 1.36 and 1.57%, respectively. The method was successfully applied for dissolution study of the developed Dextromethorphan hydrobromide tablets.
  N. Ramesh , V. Rajesh Kannan , K. Karthikeyan , K. Nanthakumar and R. Karthik Raja
  Isolation of Bluetongue virus from blood samples of sheep and goat was carried out in the present study. Out of one fifty blood samples screened for seroprevalance of BTV antibodies by Agarose Gel Precipitation Test (AGPT) 42 gave positive results. The overall percentage of virus isolation was 28% from Embryonated Chicken Eggs (ECE). The identities of the isolates were confirmed by cytopathogenicity. All the isolates were passaged twenty one times in embryonated chicken eggs and further passaged in BHK-21 cell lines. The viral isolates adapted well to the cell culture system and produced cytopathic change like grouping of cells, polycaryon, syncytica formation, acidophilic and intracytoplasmic inclusion bodies in BHK-21 cells. This study confirms the BTV incidence in the tested blood sample with a possible means showing that the virus can easily adapt to ECE and BHK-21 cell line.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility