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Articles by N. Njikam
Total Records ( 2 ) for N. Njikam
  E. Ngo Bum , M.M. Pelanken , N. Njikam , E. Talla , G.S. Taiwe , G.C.N. Nkantchoua and G.T. Ngoupaye
  The aim of this study is to scientifically look for sedative and anticonvulsant properties of the decoction of Phyllanthus discoideus Baill (P. discoideus) in mice. The in vivo models of epilepsy were used to evaluate the anticonvulsant properties of the plant. These models were maximal electroshock-, N-methyl-D-aspartate-, pentylenetetrazol-, isonicotinic hydrazide- acid and strychnine- induced convulsions or turning behavior in mice. The potentiation of sleep induced by diazepam in mice was used for the determination of the sedative properties. Four doses of the plant in the decoction were used: 17.1, 42.7, 85.5 and 171 mg kg-1. The decoction of the leaves of P. discoideus strongly increased the total sleep time (p<0.001) induced by diazepam and precipitated its onset (p<0.001). The decoction also protected mice against maximal electroshock- (p<0.001), pentylenetetrazol- (p<0.001), strychnine- (p<0.001) and N-methyl-D-aspartate- induced seizures or turning behavior (p<0.001). Finally, the decoction increased the latency to the onset of seizure in isonicotinic hydrazide acid test (p<0.001). In conclusion the decoction of P. discoideus posses anticonvulsant and sedative properties in mice. The presence of these properties could explain its use in traditional medicine in Cameroon in the treatment of insomnia and epilepsy.
  E.N. Bum , G.N. Nkantchoua , N. Njikam , G.S. Taiwe , G.T. Ngoupaye , M.M. Pelanken , Nanga , F. Maidawa , A. Rakotonirina and S.V. Rakotonirina
  Senna spectabilis DC. is a small tree, 3 to 5 m, found in tropical areas in Africa, Asia, Australia, Latino and South America. It is used in traditional medicine in Cameroon to treat many diseases (constipation, insomnia, epilepsy, anxiety, etc.). Therefore, the aim of this study was to look scientifically for the anticonvulsant and sedative properties of S. spectabilis. In vivo animal models of epilepsy (Maximal Electroshock (MES), N-Methyl-D-Aspartate (NMDA), Pentylenetetrazol (PTZ) and Strychnine (STR) induced convulsions or turning behavior) and insomnia (diazepam-induced sleep) were used. Mice were divided in six groups: one negative control group, one positive control group and four groups treated with the plant extract, (except for diazepam-induced sleep test). Four doses of the ethanolic extract were used: 100, 200, 500 and 1000 mg kg-1. The ethanolic extract of the leaves of Senna spectabilis strongly increased the total sleep time induced by diazepam (p<0.001). It also protected mice against Maximal Electroshock (MES) (p<0.01), pentylenetetrazol (p<0.001), picrotoxin (p<0.01) strychnine (p<0.01) and n-methyl-d-aspartate (p<0.001)-induced seizures and turning behavior and increased the latency to the onset of seizure in Isonicotinic Hydrazide Acid (INH) test (p<0.01). The results lead to the conclusion that the extract of Senna spectabilis possesses anticonvulsant and sedative properties in mice and could explain its used in traditional medicine in Africa, in the treatment of insomnia and epilepsy.
 
 
 
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