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Articles by N. Najati
Total Records ( 3 ) for N. Najati
  N. Najati , M. Rafeey and Melekian Taghy
  Some studies showed increased levels of proinflammatory cytokines like IL-6, IL-8 and TNF-α in the blood samples of pregnant women with PROM (Premature rupture of membranes) and their neonates. The aim of this study was to find a relationship between increased level of IL-8 and PROM, a cost benefit method for early diagnosis and reduction of hospitalization period of neonatal sepsis. This case control study was conducted in Obstetrics and Gynecology Department of Al-Zahra Hospital at Tabriz University of Medical Sciences, Iran from 10th April 2001 to 20th June 2003. We studied 50 LBW (Low birth weight) neonates born from mothers with PROM as the case group and fifty LBW neonates born from mothers without PROM as our control group Neonates born from pregnant women with PROM underwent sepsis workup and blood samples from their umbilical cord were sent for blood culture and IL-8 level measurement. Mean levels of IL-8 in study and control groups were 128.12 and 39.2 pg mL-1, respectively. We had no positive blood culture and no bacteria could be isolated. Significantly elevated values (p<0.0003) were showed in cases with PROM compared to cases without PROM (medians 67.5 pg mL-1 vs. 29.5 pg mL-1, respectively). This study showed a strong relationship between IL-8 elevation and PROM. Increased levels of IL-8 can be used as indicator for early diagnosis of neonatal sepsis.
  N. Najati , M.M. Gharebaghi and F. Mortazavi
  The purpose of this study was to determine underlying causes of prolonged neonatal icterus. Icterus or jaundice is an important common problem in neonatology. When this condition persists beyond 14 days, it is called prolonged or protracted neonatal icterus. Determining underlying causes of this problem is a pivotal step for management, because a delay in treatment may lead to serious complications or even death. In a prospective study, newborns with diagnosis of prolonged icterus were evaluated during a six-month period in Tabriz Children Teaching Hospital. Data regarding the past medical history, physical examination and appropriate laboratory and paraclinical investigations were gathered and accordingly, the underlying cause of jaundice was documented. One hundred newborns, 67 males and 33 females with a mean age of 21.5±4.5 days were enrolled. Breastfeeding, urinary tract infection, glucose 6-phosphate dehydrogenase deficiency and hypothyroidism were found as the main underlying causes in 75, 7, 7 and 4% of the cases. The exact etiology was unknown in 4% of newborns. ABO incompatibility, sepsis and Down syndrome were underlying etiologies in remaining three patients. Present study showed that the underlying causes of prolonged neonatal jaundice could be determined in majority of cases and breastfeeding is the most common one in this regard.
  N. Najati and L. Saboktakin
  This study aims at determining the prevalence of neonatal hypoglycemia and its underlying causes. In this prospective study 14168 newborns delivered in Tabriz Alzahra Hospital during 2 years were evaluated in regard to blood glucose level at first 24 h of life. Glucose oxidase method with 4-amino-phenazone with a Greiner G-300 was the used method for determining the blood glucose level. Cases with blood glucose <50 mg dL-1 were considered as hypoglycemic newborns. Underlying causes of this condition, as well as the short-term mortality rate were determined. Prevalence of neonatal hypoglycemia was 0.4% (52 newborns). Underlying causes of hypoglycemia were prematurity (61.5%), diabetic mother (13.6%), septicemia (9.6%), perinatal asphyxia (9.6%), stress (3.8%) and neonatal hyperinsulinism (1.9%). The mortality rate was 53.8%, with prematurity as the leading cause of death.
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