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Articles by N. Hanafi
Total Records ( 2 ) for N. Hanafi
  N. Hanafi and S.Z. Mansour
  The present study aims to evaluate the antitumor effect of aqueous extract of Salenostemma Argel (SA) leaves either alone or combined with 6 Gy of γ-radiation exposure against Ehrlich Carcinoma (EC) bearing mice. SA extract was gavages at the doses of 15 mg kg-1 b.wt. SA gavages to experimental animals 24 h and 7 days after Tumor Inoculation (ATI). γ-radiation exposure was done 7 days ATI as a single dose. In the present study aqueous extract of SA chemosensitivity, growth of transplantable murine tumor, apoptotic and necrotic detection in tumor tissue were done. Histopathological examination, biochemical parameters such as lipid peroxidation (MDA), glutathione content (GSH), superoxide dismutase (SOD) and catalase (CAT) activities for the murine tumor and liver tissues were also examined. SA activates tumor cell death after two weeks. SA significantly decrease tumor volume and recorded high and wide zones of apoptotic tumor cells in tumor tissue either alone or combined with γ- irradiation. SA and γ-irradiation resultant a non significant change in MDA and a non significant change in GSH level and CAT activity in tumor tissue either alone or combined with γ- irradiation. SA ameliorates MDA and significantly ameliorates GSH level and CAT and SOD activity in liver tissue of EC-bearing mice. Histopathologically SA and/or γ-irradiation represented large areas of apoptosis, hydropic degeneration and nuclear debris in tumor tissue section. However, in liver tissue SA treatment represent increase in Kupffer cells and decrease of inflammatory cells. SA and γ-irradiation represented normal appearance of liver tissue section. It is concluded that SA and/ or γ-irradiation represent antitumor activities.
  N. Hanafi
  Treatment of carbon tetrachloride (CCl4) 1 mL kg-1 in olive oil (1:1) twice a week for 8 weeks to albino male rat caused a significant increase in serum level of alanine transaminase (ALT) and aspartate transaminase (AST). Injury to liver, resulting in loss of its normal physiological/biochemical functions, may adversely affect a secondary organ like testis. In the current study young adult rats were treated by Carbon tetrachloride (CCl4) two times per week and/or continuously whole body γ-irradiated (R) at a dose level 0.5 Gy, two times per week for 8 weeks. The previous groups were treated by bone marrow transplantation (BMT). Plasma estradiol and testosterone concentrations in animals sera were analyzed. Histopathological, apoptosis and necrosis examinations were done in testicular tissues. Either CCl4 or R exposure alone or combined reflect testicular seminiferous tubules atrophy, peritubular fibrosis and apoptotic cells in seminiferous epithelium and Leydig cells. BMT reflect some recurrence of normal structure in testis tissue of CCl4 group. Meanwhile R and CCl4 R groups showed atrophied testicular seminiferous tubules, great interstitial hyperplasia, deposition of collagen fibres around blood vessels and presence of interstitial apoptotic and necrotic tissue cells. CCl4 treatment recorded anon significant change in plasma testosterone and a significant decrease in estradiol concentration. γ-irradiation either alone or combined with CCl4 treatments recorded a significant reduction in testosterone level and significant increase in estradiol concentration. BMT recorded a significant increase in testosterone level and anon significant change in estradiol level following CCl4 or irradiation either alone or combined. In conclusion low doses of γ- radiation impair testicular tissue in a rat treated CCl4 model. BM transplantation recorded increase in this testicular damage.
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