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Articles by N. Dabir
Total Records ( 3 ) for N. Dabir
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  The aim of present study was to investigate the role of opioid and α-adrenergic receptors in antispasmodic activity of Ruta chalepensis (L.) hydroalcoholic extract (RCHE) in rat ileum contractions induced by KCl. A piece of ileum (2 cm) was dissected out from male Wistar rats and mounted in an organ bath containing air bubbled Tyrode solution (37°C). Isotonic Transducer is exceptionally sensitive and stable and connected to Harvard Universal Oscillograph (UK). The tissue was under 1 g initial tension and contractions were recorded isotonically. The RCHE was prepared by macerated with alcohol (70%). Ileum was contracted by KCl (60 mM) and cumulative concentrations of RCHE were applied (0.01-0.07 mg mL-1) before and after tissue incubation (30 min) with naloxon (1 μM) or phentolamine (1 μM). RCHE reduced KCl-induced contraction in a concentration dependent manner (p<0.001). However, tissue incubation with naloxone and phentolamine attenuated the spasmolytic effect of RCHE (p<0.001). We conclude that in the antispasmodic activity of RCHE, at least in part, the opioid and α -adrenergic receptors are involved.
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  In this study, the effect of Ruta chalepensis on rat’s ileum contraction has been investigated because the hydroalcoholic extract of the leave of Ruta chalepensis, grown in Iran were investigated for pharmacological properties. Ruta chalepensis (Rue) is annual herb is used in the traditional medicine in Iran for intestinal disorder. In this study the effect of hydroalcoholic extract of Rue on isolated rat’s ileum contraction was investigated by KCl (60 mM). A segment of ileum was removed and suspended in 10 mL organ bath containing aerated Tyrode solution (37 °C, pH = 7.4).The responses were determined and recorded on isotonic transducer and Harvard Universal Oscillograph. The result demonstrate that the extract significantly reduced the ileum contraction induced by KCl (60 mM) in a dose dependent manner (n = 7, p<0.001). Also, adding extract before influence of KCl, cause reduce effect of KCl (n = 7, p<0.001). In another study, in high potassium Ca2+-free tyrode solution, cumulative concentrations of CaCl2, induced ileal contraction, however, the extract reduced these contractions in a dose dependently (n = 7, p<0.001). Therefore, the results suggest that relaxatory effect of rue on the ileum may be due to blocking of voltage gated calcium channels.
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  The aim of present study was to investigate the effect of hydroalcoholic extract of Ruta chalepensis (Rutaceae) leaves on rat ileum contractility and possible mechanism(s) involved. Ruta chalepensis extract was prepared by maceration method (ethanol 70%). Terminal portion of ileum (2 cm) was dissected out from male Wistar rats and mounted in an organ bath containing air bubbled Tyrode solution with 1 g initial tension and ileal contraction induced by KCl (60 mM) was recorded. The spasmolytic effect of the cumulative concentrations of extracts (0.01- 0.07 mg mL-1) was reduced after tissue incubation with L-NAME (100 μM, 20 min). Methylene blue (30 μM) reduced the extracts (0.01-0.07 mg mL-1) spasmolytic effect (p<0.001). Furthermore, it seems that the portion relaxatory effect of Rue extract on the rat ileum may be due to nitric oxide and the antispasmodic activity of the extract was mainly through a cGMP-dependent mechanism.
 
 
 
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