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Articles by N. Anitha
Total Records ( 2 ) for N. Anitha
  T. Gandhimathi , N. Anitha and M. Latha
  In this study, we study some of the properties of interval valued Q-fuzzy subhemiring of a hemiring under is omorphism and anti-is omorphism. Also prove that the homomorphic image and anti-homomorphic image of an interval valued Q-fuzzy normal subhemiring is an interval valued Q-fuzzy subhemiring.
  N. Anitha , J.V. Rao , S. Kavimani and V. Himabindu
  The present study is aimed to explore the pharmacodynamic interaction of metformin with statins like atorvastatin and rosuvastatin in rats. Wistar albino rats of either sex (150-200 g) were induced diabetes by administering alloxan and they were divided into six groups, each consisting of six rats. Normal control group (1) is treated with 1%w/v carboxy methyl cellulose (CMC) suspension. Group 2 served as diabetic control. To the diabetic 3rd, 4th and 5th group metformin, atorvastatin and rosuvastatin were administered orally respectively for 7 days. The combination of metformin + atorvastatin and metformin + rosuvastatin were administered to the 6th and 7th group of diabetic rats for 7 days. On the last day blood samples were collected, serum was isolated and subjected to glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) estimation. Body weight was also calculated. Metformin significantly reduced the serum glucose level in diabetic rats. Atorvastatin and rosuvastatin produced mild hypoglycemia. On the other hand the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the serum glucose level when compared to metformin alone. Atorvastatin and rosuvastatin significantly reduced the serum TG, TC and LDL and increased HDL level. Metformin also altered the lipid profile of diabetic rats. Whereas the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the lipid profile when compared to atorvastatin and rosuvastatin alone. The combination of drugs also increased the body weight of diabetic animals. The antidiabetic drug metformin enhanced the hypolipidemic activity of atorvastatin and rosuvastatin. Similarly atorvastatin and rosuvastatin enhanced the hypoglycemic activity of metformin due to pharmacodynamic interactions.
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