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Articles by N. M Krah
Total Records ( 1 ) for N. M Krah
  A Stahl , P Sapieha , K. M Connor , J. P SanGiovanni , J Chen , C. M Aderman , K. L Willett , N. M Krah , R. J Dennison , M. R Seaward , K. I Guerin , J Hua and L. E. H. Smith
  Rationale:

Omega3 long-chain polyunsaturated fatty acids (3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing 3-PUFA–dependent attenuation of angiogenesis.

Objective:

This study aims to identify a major mechanism by which 3-PUFAs attenuate retinal neovascularization.

Methods and Results:

Administering 3-PUFAs exclusively during the neovascular stage of the mouse model of oxygen-induced retinopathy induces a direct neovascularization reduction of more than 40% without altering vasoobliteration or the regrowth of normal vessels. Cotreatment with an inhibitor of peroxisome proliferator-activated receptor (PPAR) almost completely abrogates this effect. Inhibition of PPAR also reverses the 3-PUFA–induced reduction of retinal tumor necrosis factor-, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.

Conclusions:

These results identify a direct, PPAR-mediated effect of 3-PUFAs on retinal neovascularization formation and retinal angiogenic activation that is independent of vascular endothelial growth factor.

 
 
 
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