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Articles by N. John Sushma
Total Records ( 4 ) for N. John Sushma
  N. John Sushma , U. Sivaiah , N. John Suraj and K. Jayantha Rao
  Exposure to sublethal dose (3.5 mg kg-1) of aluminium acetate has revealed significant changes in LDH, ICDH, SDH and GDH in brain, liver and kidney of albino mice. These changes are highly significant in multiple dose treated individuals compared to single and double dose aluminium acetate administered mice. In order to understand the energy related alterations in glycolysis and Kreb’s cycle the activity levels of the selected dehydrogenases were estimated. The lactate dehydrogenase (LDH) activity showed increase in the tissues, where as succinic dehydrogenase (SDH) and isocitrate dehydrogenase (ICDH) were decreased in the tissues of aluminium acetate administered albino mice. The increased levels of LDH and decreased levels of SDH and ICDH confirms a shift in normal balance of glycolysis in favour of anaerobiasis. Glutamate dehydrogenase (GDH) activity was found to be elevated in all the tissues of aluminium acetate treated mice. The elevated GDH activity levels indicate its contribution to ammonia production and glutamate oxidation.
  T. Madhavi , B. Mahitha , K. Mallikarjuna and N. John Sushma
  In the present study the pro-oxidant activity of aluminum (Al) and the protective role of Bacopa monniera extract (BME) were determined in the medulla oblongata of albino rats. Albino rats were divided into four groups. First group of rats was used as control, second group of rats received oral dose of Aluminum maltolate only, third group of animals received Bacopa monniera extract (BME) and fourth group of animals received concurrently Aluminum maltolate (Al-M) plus Bacopa monniera (BME) extract respectively, for 4 weeks. At the end of the treatment, the medulla oblongata was removed and processed to examine the thiobarbituric acid reactive substances (TBA-RS) and antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx). Oxidative stress was promoted in medulla oblongata following Aluminum administration. In contrast, BME extract exerted an antioxidant action which was related with an increase in the levels of antioxidant enzymes. Moreover, evidences from light microscopic images clearly demonstrating that Al-M-induced neuronal changes, which were minimized by BME treatment, architecture of medulla oblongata in Al-M+BME treated group was almost similar to the control.
  N. John Sushma , U. Sivaiah , N. John Suraj and K. Jayantha Rao
  Recently, aluminium (Al) has been identified as one of the environmental factors responsible to cause certain neurodegenerative diseases, particularly Alzheimer`s Disease (AD). However, the relationship between Al and AD is controversial. We examined aluminium induced oxidative stress in the brain of mice when aluminium acetate was administered. Albino mice were divided into four groups containing 10 animals each. The first group of animals were treated as controls and administered distilled water, to the second group of animals single dose of aluminium acetate (3.5 mg kg-1 body weight) was given. To the third group of animals double doses (7 mg kg-1 body weight) were given with 72 h interval. To the 4th group of animals multiple doses (14 mg kg-1 body weight) with 72 h interval were given. Exposure to sublethal dose (3.5 mg kg-1) of aluminium acetate has revealed significant variations in detoxification enzymes like xanthine oxidase (XOD), superoxide dismutase (SOD), catalase (CAT) and Lipid Peroxidation (LP) in different regions of brain (cerebral cortex, cerebellum, striatum, medulla) of albino mice. Present results revealed that aluminium acetate exposure increased the activities of XOD, SOD, CAT and LP in all the brain regions in a dose dependent manner, so that it induced the oxidative stress in brain of albino mice.
  K. Mallikarjuna , G.R. Dillip , G. Narasimha , N. John Sushma and B. Deva Prasad Raju
  Nanotechnology can be defined as a research for the design, synthesis and manipulation of structure of particles with dimension smaller than 100 nm. Nanotechnology emerges from the physical, chemical, biological and engineering sciences where novel techniques are being developed to probe and manipulate single atoms and molecules. The biomimetic approaches of silver nanoparticles were reduced by a simple and eco-friendly process. The advantage of using plants for the synthesis of nanoparticles is that they are easily available, safe to handle and possess a broad variability of metabolites that may aid in reduction. We report a biomolecules hosting, rapid, environmentally benign, bio-degradable, non-toxic and green synthesis of silver nanoparticles by using Piper betle leaf broth as a reducing and stabilizing agent. The sizes of synthesized silver nanoparticles were formed on the treatment of aqueous AgNO3 solution with Piper betle broth, in the range of 3-37 nm. A UV visible spectrum of the aqueous medium containing silver ions demonstrated a peak at 440 nm corresponding to the surface plasmon resonance of silver nanoparticles; An XRD analysis reveals the crystalline nature of silver nanoparticles. The FTIR spectrum suggests that the proteins act as capping agents around the nanoparticles. The size and shape of the nanoparticles were employed by the Transmission Electron Microscope (TEM).
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