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Articles by Munish Garg
Total Records ( 6 ) for Munish Garg
  Meenu Mehta , Saurabh Satija , Arun Nanda and Munish Garg
  Boswellic Acids (BAs) are the main ingredients of Boswellia serrata (Family: Burseraceae) gum resin extract for the treatment of a variety of inflammatory diseases besides acting as both internal and external stimulant, expectorant, diuretic and stomachic. Despite its multipurpose benefits, BAs have low oral bioavailability especially 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA), (the most therapeutically potential BAs) because these BAs are lipophilic in nature and not solubilises into the intestinal fluid thus limiting its systemic availability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years has witnessed the encouraging progress in the use of nano scale drug delivery systems on BAs such as loading BAs into liposomes, solid lipid nanoparticles as well as the latest reported technologies such as niosomes, phytosomes and nanomicelles etc. This review summarizes the recent works on the design and development of nanoscale delivery systems of BAs, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena.
  Vivek Kumar Gupta , Rachna Kumria , Munish Garg and Monika Gupta
  Flavonoids are low molecular weight, polyphenolic compounds present in majority of vascular plants, possessing many therapeutic activities vis a vis antioxidant activity. The present review discuss the chemical nature, mechanism of action, current status, pharmacodynamic/pharmacokinetic studies, industrial significance, nutritive value in health system and analysis of flavonoids with the recent technology.
  Pardeep Kumar , Meenu Mehta , Saurabh Satija and Munish Garg
  Controlling post-prandial hyperglycaemia through enzymatic inhibition of starch degradation is an effective therapeutic approach in the management of diabetes mellitus. To achieve this, twelve indigenous antidiabetic Indian medicinal plants such as Trigonella foenum-graecum, Ocimum sanctum, Aegle marmelos, Plantago ovata, Catharanthus roseus, Alium cepa, Azadirachta indica, Aloe vera, Magnifera indica, Terminalia chebula, Eugenia jambolana and Linum usitatisumum were subjected to sequential solvent extraction and thereafter, 48 fractions were screened for their α-amylase inhibitory potential at three dosage levels in vitro. Out of the 144 samples, Eugenia jambolana water extract showed maximum α-amylase inhibitory activity with IC50 value 1.33 mg mL-1 in comparison with standard drug acarbose (IC50 value 0.86 mg mL-1). Quantitative phytochemical analysis of the lead extract revealed the presence of phenolic content as 69.68 mg tannic acid equivalent g-1 while flavonoidal content as 57.39 mg rutin equivalent g-1. Present study indicated Eugenia jambolana as a potential α-amylase inhibitor in the management of diabetes.
  Saurabh Satija , Preeti Bansal , Harish Dureja and Munish Garg
  Present study was conducted to develop a new optimized Microwave-Assisted Extraction (MAE) method for Tinospora cordifolia in order to improve the efficiency and yield of chief bioactive compounds. Stems of the Tinospora cordifolia were subjected for extraction using MAE technique using three variable factors (extraction time, irradiation power and solvent concentration) optimized through central composite design. Berberine which was used, as marker was estimated in prepared extract by High Performance Thin Layer Chromatography (HPTLC) and compared with extracts prepared by conventional techniques like maceration and soxhlation. The results revealed that MAE of Tinospora cordifolia at 60% irradiation power, 80% ethanol concentration and at 3 min extraction time produced highest extract yield (91.3% better yield than maceration and 25.7% than soxhlation) as well as berberine content (492.8% better than maceration and 59.6% than soxhlation) as compared to extracts prepared with conventional techniques. Efficiency of the MAE method was considerably better than the conventional procedures, especially in terms of shortening extraction time (3 min as compared to 3 h for soxhlation and 7 days fort maceration), reduction of solvent used and energy consumption. The optimized microwave extraction method can provide a valuable extraction alternative of Tinospora cordifolia stem at industrial scale.
  Monika Joon and Munish Garg
  Several technological advances have been made in the recent years to overcome skin barrier properties and to enhance drug penetration. In this regard, transdermal drug delivery system provides a suitable solution of the problems associated with conventional routes of drug administration. In the present study, Withania somnifera leaf extract loaded proniosomal gel was prepared and evaluated for better delivery and improved anti-inflammatory property. The formulated gel was characterized for vesicle physical analysis, entrapment efficiency and in vitro release study. The method used for preparation of proniosomal gel resulted in higher drug entrapment value of 87.2%. Scanning electron microscopy analysis showed that the surface of the particles was smooth. The formulations showed prolonged in vitro drug release of 60.8% over a period of 24 h and significant anti-inflammatory response. From this study, it is concluded that proniosomes are very stable and promising delivery system for Withania somnifera leaf extract.
  Meenu Mehta and Munish Garg
  Dermal delivery of drugs through proniosome gel is a recent candidate receiving considerable attention. Boswellic Acids (BAs) are pentacyclic triterpenoids; the major constituents of the gum resin derived from the plant Boswellia serrata (family Burseraceae). The BAs have low oral bioavailability due to its lipophilic nature and high first pass metabolism. Proniosomes offer an acceptable vesicle delivery concept with the potential for transdermal drug delivery. This review covers various aspects of proniosomes including mechanism, methods of preparation emphasizing on scope and potential of proniosomal gel as a potential delivery system for boswellic acids.
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