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Articles by Munir Ahmad Sheikh
Total Records ( 3 ) for Munir Ahmad Sheikh
  Shakeela Naz , Tahira Iqbal , Munir Ahmad Sheikh , Muhammad Shahid and Abdul Ghaffar
  Brevibacterium flavum maintained at 7.0 pH level and at 37 °C temperature, gives maximum production of lysine. When the organism was given UV shocks for 30 minutes, gave the lysine in maximum quality. Water substrate ratio, addition of molasses, addition of corn steep liquor were optimized. At 40% water substrate ratio, addition of 4% corn steep liquor and 4% molasses bacteria was most efficient in the production of lysine. The biomass thus produced contained 32.8% crude protein, 20.87% true protein, 34% ash and 1.1% fat contents on the basis of dry matter. There was no increase or decrease in ether extract and crude fiber. The biomass produced was analyzed by three-enzyme method. Its digestibility was 85.69% in single cell protein biomass. Amino acid profile showed that lysine production was 21.48mg/g on the basis of protein.
  Asma Nafeesa , Munir Ahmad Sheikh , Ikram-ul-Haq , Amer Jamil and Zahida Parveen
  A total of 60 isolates of Staphylococcus aureus, 30 each from upper respiratory tract as well as from post operative wound infections were subjected to antibiogram studies. Staph. aureus isolates from upper respiratory tract were found 30, 53.33 and 43.33% resistant against ciprofloxacin, amoxycillin and chloramphenicol respectively. A similar pattern of antibiotic resistance was observed against the bacterial isolates from post operative sepsis. Susceptibility of ciprofloxacin, amoxycillin and chloramphenicol in such cases was found only to be 43.33, 10 and 3.33% respectively. The high bacterial resistance appears to be due to indiscriminate use of antibiotics.
  Nafeesa Waheed , Tahira Iqbal , Munir Ahmad Sheikh and Faqir Hussain Khan
  The objective of the study was to evaluate the renal clearance of levofloxacin and that of the endogenous creatinine, following a single oral dose of 500 mg of levofloxacin to eight healthy male volunteers. After an over night fasting control and after drug administration blood and urine samples were collected at 0,30, 60, 90, 120, 150 and 0, 45 ,75, 105, 135 ,160 minutes time intervals, respectively. The samples were assayed for endogenous creatinine spectrophotometrically and levofloxacin by microbiological assay. Mean± SE values for the blood and urine pH were 7.548 ± 0.013 and 5.85 ± 0.0039, respectively. The average±SE value for diuresis was 0.018± 0.0056ml min-1 kg-1. The average± SE values for renal clearance of endogenous creatinine and levofloxacin were 0.519±0.068 and 0.778±0.110ml min-1 kg-1. The study performed in summer showed that with an increase in urine flow the renal clearance of levofloxacin also increase, and statistically there is non-significant positive correlation (R2=0.647) between these two parameters. These variations in results supporting the findings that there is a need to evaluate the imported drugs under indigenous conditions due to environmental difference, for getting optimal therapeutic results.
 
 
 
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