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Articles by Mukesh Sahu
Total Records ( 2 ) for Mukesh Sahu
  Jozef Borvak , Mukesh Sahu , Varun Joy , Jyotsana Singhal , Sushma Yadav , Larry Xavier Oakford , Sejong Bae , Poorna Chandra Rao Lelsani , Amit Nangrani , Sharad Swaroop Singhal , Yogesh Chandra Awasthi and Sanjay Awasthi
  Problem statement: Dendritic Cells (DCs) integrate responses of innate and adaptive immune system via transmitting pro-inflammatory and regulatory signals to naive cells within draining lymph nodes. DCs have high capacity for endocytosis, both Clathrin-Dependent (CDE) and Caveolin-Dependent (CvDE). Approach: We have recently shown that ATP-hydrolysis by the multifunctional transporter protein RLIP76 is the primary determinant of the rate of CDE. Activation of CDE is necessary for DCs to internalize and process exogenous antigens. Thus, in present studies we investigated the role of RLIP76 in antigen uptake, maturation and T cell priming capacity of monocyte-derived DCs. Results: Using flow cytometry, we demonstrate variable surface expression of RLIP76 on immature DCs generated from peripheral blood mononuclear cells from healthy individuals. Studies on the effect of anti-RLIP76 antibodies on endocytosis of DC-specific C-type Lectin Receptors (CLRs) (DC-SIGN and DEC-205) and on co-localization of these receptors with MHC-class II were conducted using confocal microscopy. RLIP76-specific antibodies suppressed the maturation of DCs and the expression of typical activation markers and co-stimulatory and adhesion molecules including CD83, HLA-DR, HLA-ABC, CD40, CD80 and CD38. They also inhibited the stimulating potency of DCs in allogeneic Mixed Leukocyte Reaction (allo-MLR). Conclusions: We conclude that RLIP76 is necessary for activation, membrane trafficking and functional maturation of DCs. Further exploration of the role of RLIP76 in DC biology is warranted and may provide promising means in DC-based immunotherapies.
  Sandeep Shukla , R.B. Sharma and Mukesh Sahu
  Background and Objective: Many air pollutants seriously affect morphological traits of the plant. Dust is the major and important part of air pollutants, generated by coal mines, thermal power plants, cement industries, cursor industries, road transport etc. When this dust comes with contact with the plants it cause many negative effects on morphology and physiology of the plant. Materials and Methods: In this study, dust deposition on the leaves decrease the productivity e.g., chloroplast content, stomatal blockage etc. Korba is the industrial city of the Chhattisgarh state. Many coal based power plant and coal mines are situated here which produced plenty of dust. In this study three parameter have been taken e.g., dust load, leaf area and pH of leaf wash and tried to understand effect of dust on Mangifera indica, the Mango plant. Results: In this study four different sites have been selected where thermal power plants and coal mining produce plenty of dust and ash particles. Leaves collected from the Korba, which is mining area are suffering badly from dust stress. Conclusion: During the study we observed that leaves of the Mangifera indica have been damaged morphologically and physiologically due to the dust. Dust load and high pH cause physical injury, necrosis, stomata blockage, reduce photosynthesis etc. Dust pollution decreases the economical and nutritional value of the Mango.
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