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Articles by Muhammad Ahmed
Total Records ( 3 ) for Muhammad Ahmed
  Mohammed Hasan Mukhtar , Waleed Hassan Almalki , Aisha Azmat , Mohammad Raafat Abdalla and Muhammad Ahmed
  Background and Objective: In folkloric medicine from Asia, Acacia tortilis (Forssk.) Hayne is used for the treatment of Diabetes Mellitus (DM). This study aimed to investigate the antidiabetic effect of ethanolic extracts of Acacia tortilis leaves (ELAT) and its protective effect in preventing the secondary complications of diabetes mellitus. Materials and Methods: Different doses of ELAT (50, 100 and 150 mg kg–1) were administered orally and their effects were studied in normal, glucose-loaded and STZ-induced diabetic rats. Data obtained from results was compared using one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison tests. Results: In all experiments, ELAT caused a significant reduction (p<0.05) in blood glucose levels. The effect was pronounced at the doses of 50, 100 and 150 mg kg–1 and also showed improved activity as compared to glibenclamide used as a reference drug. The ELAT was found to be safe at the dose of 2000 mg kg–1, as no mortality was observed. For hepatic function test, marker enzymes were not changed markedly in ELAT-treated rats. The lipid profile showed a significant reduction (p<0.05) in the levels of serum cholesterol, LDL and triglyceride. Conclusion: It is concluded that the leaf ethanolic extract of Acacia tortilis has antidiabetic activity. It also decreased the lipid profile in rats. This justifies the traditional use of plant. It serve as a natural source for antidiabetic drugs in whom hyperglycemia and hypercholesterolemia quite often coexist.
  Abdulhalim S. Serafi , Aisha Azmat , Muhammad Ahmed , Mohammed Bafail and Zahir Hussain
  Background and Objectives: Herbal medicines are recommended as remedy for different cardiac diseases. Acacia possessing significant pharmacological activities, widely found in KSA. The effect of Acacia tortilis leaves decoction (ATLD) on cardiac hemodynamics was evaluated in rats. Methods: Different hemodynamic parameters (systolic, diastolic, mean arterial blood pressure and heart rate) were recorded in normotensive rats before and after the intravenous administration of ATLD. Results: The different doses showed a dose dependent significant hypotensive effect. However the highest dose (30 mg kg–1) showed maximum activity and lowered the systolic pressure (17.4±2.95%), diastolic blood pressure (15.2±1.8%) and mean arterial blood pressure (17.1±2.4%). Intravenous administration of ATLD also showed a dose-dependent reduction in heart rate (p<0.001). Conclusion:The hypotensive and bradycardia might had been due to presence of N,N Dimethyltryptamine in extract that reduced the blood pressure and heart rate. Thus, the authors conclude that the ATLD possesses potent hypotensive activity and sought to be useful for anti hypertensive drug development and worth much merit to be investigated.
  Abdul Halim Serafi , Aisha Azmat , Ruqaiya Hasan and Muhammad Ahmed
  Background and Objective: Over the past several decades, an increase in the consumption of sugar-sweetened beverages (SSBs) has coincided with rising rates of obesity. This study was conducted to evaluate the association between SSBs consumption and Body Mass Index (BMI) among female university students. Materials and Methods: An online structured survey form was used to collect the data on SSBs consumption and BMI in Saudi Arabia. Results: One way ANOVA found significant differences in mean BMI across various consumption frequencies of SSBs (p<0.001). An increased risk of being obese (high BMI: 30 or more) was associated with increased total consumption and consumption frequency of SSBs (p<0.05). Conclusion: This study found that mean BMI was positively associated with SSBs consumption. These significant results indicate that consumption of SSBs increases the risk of obesity.
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