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Articles by Muhammad Shoaib Akhtar
Total Records ( 5 ) for Muhammad Shoaib Akhtar
  Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan
  Polygonum viviparum, root has been used in the folkloric medicine for the treatment of a many diseases including gastrointestinal disorders. Powdered roots of Polygonum viviparum (PV) and its aqueous (PV-A) and ethanol (PV-E) extracts were evaluated for anti-ulcerogenic efficacy in rats with ulcer lesions in the glandular stomach induced by indomethacin (25 mg kg-1)subcutaneously, to rationalize the folkloric uses. The pretreatment of PV protected the experimental rats against gastric changes caused by indomethacin in a dose-dependent manner. PV-A and PV-E extracts (equivalent to 2.0 g kg-1) of the powder also inhibited the indomethacin-induced effects on gastric juice volume, pH, acid-output and ulcer index. PV, PV-A and PV-E showed highly significantly in vitro acid buffering and pepsin binding activities. The data indicates that PV and its extracts protect the gastric mucosa against indomethacin-induced gastric changes, may result from their lipid peroxidation/apoptosis inhibition.
  Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan
  Although introduction of modern drugs to the classic anti-ulcer therapy has been revolutionized the treatment of peptic ulcer but the complete cure of the disease has yet to be discovered. In an effort to explore indigenous medicinal plants the powdered leaves of Cichorium intybus (CI) and its extracts i.e., aqueous, ethanol, were investigated for their anti-secretary and anti-ulcer activities in the albino rats (Sprague-Dawley, weighing 180-220 g) with gastric ulcer induced by indomethacin (25 mg kg-1, subcutaneous). The treatment of CI attenuated the indomethacin-induced changes in gastric juice volume, pH, acid-output and ulcer index in a dose-dependent manner. The aqueous (CI-Aq) and ethanol (CI-E) extracts (equivalent to 2.0 g kg-1 of body weight) of the powder also protected the rats against gastric effects induced by indomethacin. CI and its extracts showed significant acid buffering in vitro activities. The findings indicate that CI and its extracts possess active principle(s) that protect the gastric mucosa against indomethacin-induced gastric changes, possibly due to its antioxidant effect that inhibits lipid peroxidation.
  Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan
  In the present study, extracts from four folkloric medicinal plants, previously reported potential anti-ulcer; Anethum graveolens L. fruit, (AG), Cichorium intybus L. leaf, (CI), Plantago ovata L. seed husk (PO) and Polygonum viviparum, L. root, (PV), were screened for anti-Helicobacter pylori (HP) activity. Anti-HP activity of the powdered drugs extracted by water, ethanol, ethyl acetate and acetone, obtaining yields of 2.34-13.43 g kg-1 (w/w), by using the turbidity method was determined. The aqueous extract exhibited the lowest minimum inhibitory concentrations (MICs) against H. pylori strain (obtained from ulcer patients), of which ranged from 0.6 to 10.5 mg mL-1, followed, in ascending order, by the Cichorium intybus leaf (CI), Polygonum viviparum root (PV), Anethum graveolens fruit (AG) and Plantago ovata seed husk (PO). Antibacterial activity was determined CI, PV, PO, AG extracts, with the highest percentage of inhibition (1.2-62.6%) demonstrated for the water, followed, in descending order, by the ethanol, ethylacetate and acetone analogs. Anti-HP activity appeared to be in a dose-dependent manner. The extracts (aqueous and ethanol) of CI and PV due to potent and AG and PO due to the moderate potent anti-H. pylori activities might ultimately be proved, the preferred and curative anti-ulcer agent.
  Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan
  Anethum graveolens, fruit has been used in the oriental medicine for the treatment of a variety of diseases including gastrointestinal disorders. The fruit powder of Anethum graveolens (AG) and its extracts were investigated for anti-secretary effects in rats with erosions on the glandular stomach induced by subcutaneous administration of 25 mg kg ha-1 indomethacin, to rationalize the folkloric uses. The pretreatment of AG protected the rats against gastric effects induced by indomethacin in a dose-dependent manner. The aqueous (AG-A) and ethanolic (AG-E) extracts (equivalent to 2.0 g kg ha-1 ) of the powder also attenuated the indomethacin-induced changes in gastric juice volume, pH, acid-output and ulcer index. AG and its extracts also showed significant acid buffering activities in vitro. The in vitro pepsin binding activity of AG was found significant while insignificant with AG-A and AG-E. These findings indicate that AG and its extracts protect the gastric mucosa against indomethacin-induced gastric changes, may result, from their antioxidant effect, which inhibits lipid peroxidation.
  Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan
  Nigella sativa, seeds has been used in traditional medicine for the treatment of a variety of diseases including gastrointestinal disorders. N. sativa seed powder (NS), its extracts and purified fractions were studied for their possible gastroprotective effects in the indomethacin-treated rats (adult albino male rats weighing 180-220 g) to rationalize the folkloric uses. NS protected the rats against indomethacin-induced gastric effects in a dose-dependent manner. The ethanolic extract of the powder (NS-E) also attenuated the indomethacin-induced changes in gastric juice volume, pH, acid-output and ulcer index. Partition of ethanol soluble ingredients in organic solvents yielded semi-purified fractions whose anti-ulcer activity guided further chemical purification. The active fraction w as chromatographically characterized and the most purified fraction (NS-EA 51) obtained, presented anti-ulcerogenic activities in indomethacin-induced gastric ulcers in the rats. Various parameters including gastric juice volume, pH, acid-output, ulcer index and peptic activity showed that it was the most potent anti-ulcerogenic fraction which gave results comparable to Famotidine. The gastroprotective or anti-secretary, anti-peptic and anti-ulcerogenic actions of NS-EA 51 might be related to its anti-inflammatory and/or antioxidant activity.
 
 
 
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