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Articles by Muhammad Iqbal CHOUDHARY
Total Records ( 3 ) for Muhammad Iqbal CHOUDHARY
  Taous Khan , Mansoor Ahmad , Waqar Ahmad , Qazi Najam us Saqib and Muhammad Iqbal Choudhary
  The present study aimed to evaluate the possible antispasmodic and lipoxygenase inhibitory activity of some Pakistani medicinal plants. Extracts from Aconitum laeve Royle (Ranunculaceae), Trichodesma indicum Linn. (Boraginaceae), and Sauromatum guttatum Schott (Araceae) (corms) were tested on the isolated rabbit jejunum. All the extracts caused reduction in spontaneous and acetylcholine-induced contractions. A. laeve displayed excellent spasmolytic activity and almost (95%) diminished the normal contraction of rabbit jejunum at a concentration of 0.25mg/mL of final bath. T. indicum inhibited the intestinal contractions by 78% at 5mg/mL while S. guttatum (corms) caused 69% inhibition of spontaneous contractions at a concentration of 2mg/mL. Extracts from A. laeve, T. indicum, S. guttatum (leaves and berries) and Paeonia emodi Wall. (Paeoniaceae) were screened in vitro for lipoxygenase inhibitory activity. All the extracts except A. laeve, showed good to excellent inhibition of the tested enzyme. P. emodi and S. guttatum (leaves) each inhibited the enzyme by 90% while T. indicum and S. guttatum (berries), respectively, showed 64.5% and 65% inhibitory activity against this enzyme.
  Nine secondary metabolites-artemetin (1), casticin (2), 3-hydroxy-5,6,7,4'-tetramethoxy flavone U(3), penduletin (4), p-hydroxybenzoic acid (5), methyl 3,4-dihydroxybenzoate (6), methyl isovanillate (7), vanillic acid (8), and 3,4-dihydroxybenzoic acid (9)-were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-9 were identified using spectroscopic techniques. Compound 7 was isolated for the first time from this plant. These compounds were screened for their antioxidant activity. Compounds 6 and 9 exhibited significant activity against the DPPH free radical.
  AZIZUDDIN and Muhammad Iqbal CHOUDHARY
  Biotransformation of danazol (17β-hydroxy-17 α-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17β-hydroxy-2-(hydroxymethyl)-17α -pregn-4-en-20-yn-3-one (2) and 17β-hydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.
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