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Articles by Mudasir Bashir Gugjoo
Total Records ( 4 ) for Mudasir Bashir Gugjoo
  Mudasir Bashir Gugjoo , Amarpal , Prakash Kinjavdekar , Hari Prasad Aithal , Abhijit Motiram Pawde , Deepti Bodh and Gutulla Taru Sharma
  The cancer stem cell concept is currently seen as an important breakthrough in cancer research and relies upon the availability of the cancer stem cells. The cells have capability to produce whole tumor mass through self-renewal and differentiation besides, the ability to metastasize possibly through homing. Since such properties are also expressed by the normal stem cells, more research is needed in this field, especially in isolation and characterization. As the conventional therapies are effective only against the bulk of the tumor without any effect on cancer stem cells, it normally relapses. It seems logical to target the cancer stem cells through direct or indirect means along with the conventional therapies, in order to devise effectual therapeutics for cancer. The current review briefly throws light upon the development of the cancer stem cell theory and its concepts besides the possible therapeutic implications.
  Mudasir Bashir Gugjoo , Amarpal , Prakash Kinjavdekar , Hari Prasad Aithal , Mohd Matin Ansari , Abhijit MotiRam Pawde and Gutulla Taru Sharma
  Mesenchymal stem cells are recognised based upon the plastic adherence, fibroblastic morphology, expression of certain surface markers, non-expression of haematopoetic markers and their ability to differentiate into atleast three lineages viz., adipogenic, chondrogenic and osteogenic. The rabbit Mesenchymal Stem Cells (rMSCs) though used extensively in research but have not been thoroughly studied and are not compared to other species. The present study was therefore conducted to determine the morphology, surface markers and trilineage differentiation potential of New Zealand white rabbit MSCs. Isolation of rMSCs was done by an established method of density gradient method using Ficoll-hapaque. The cells were characterised by Phase Contrast Microscopy, Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Alkaline Phosphatase (AP) staining. The cells isolated were plastic adherent and had fibroblastic spindle shape with eccentric irregular nuclei. The cells expressed surface markers viz., CD 105 and CD 106 besides expressing genes of collagen type II and I. Haematopoetic markers (CD 34 and CD 45) and aggrecan gene however, were not expressed. The rMSCs showed a moderate alkaline phosphates activity. Trilineage differentiation was conducted utilizing prepared differentiation media and rMSCs were differentiated into corresponding cell lineages based upon the medium used. It was concluded that rMSCs possess morphology similar to other species with good proliferation rate and exhibit the characteristics laid down by International Society for Cellular Therapy (ISCT). The present study provided basic protocols for characterization of rabbit MSCs that should be used before application of these cells for any research or therapy.
  Ahmed Abdelbaset-Ismail , Mudasir Bashir Gugjoo , Alaa Ghazy , Mohamed Gomaa , Ahmed Abdelaal , Amarpal , Ahmed Behery , Abdel-Basit Abdel-Aal , Mohamed-Tayiser Samy and Kuldeep Dhama
  There is no doubt that the donkey, as a drafting animal, plays a critical role in the developing communities for both agriculture production and riding purposes. Therefore, to maintain healthy skeleton in these animals, the understanding of radiographic anatomy of ossification centers and growth plates (locations, types and closure times), need to be advanced. It is imperative that an appropriate maturation point is reached to avoid early overexertion of the donkey and the resulting irreparable damage. It is therefore the aim of this review is to highlight the importance of expanding the limited dataset on epiphyseal growth plate maturation and begin to define its ossification times in the donkey. Moreover, it has been recently proposed that the receptors of gonadal sex hormones including estrogen androgen as well as pituitary sex hormones including luteinizing hormone and prolactin are localized in human and animal growth plates. This indicates that these hormones actively participate in the chondroregulation mechanisms at the ossification growth plates. A connection with that, we noticed that the more primitive stem cells as well as hematopoietic stem cells and mesenechymal stem cells express these receptors as well. Therefore, it would be very interesting to address the link between sex hormones and ossification time of growth plates, as well as the sharing activities of these stem cells during the ossification process.
  Mudasir Bashir Gugjoo , Mozammel Hoque , Abhishek Chander Saxena and Malik Mohamed Sham-Suz Zama
  Breed-wise standard electrocardiographic values in dogs have been reported as there is variation in body and chest conformation, which limits the application of data of one breed for other breed. Labrador retrievers being originated from hunting dogs, their electrocardiogram (ECG) values might be different from standard normal range of other dog breeds. So, the purpose of the present study was to determine the standard ECG of Labrador retrievers and to check effect of body weight, gender and breed upon different ECG parameters. Six-lead ECGs, three bipolar standard limb leads (I, II and III) and three augmented unipolar limb leads (aVR, aVL and aVF), were taken from 24 Labrador retrievers positioned in right lateral recumbency without any chemical restraint. Amplitude and duration of P wave and QRS complex, PR interval, QT interval and mean electrical axis and heart rate were measured in each recording. Non-significant effect of gender and body weight was seen on all the ECG waves. Deep Q waves in Leads I, II and aVF and variation in relation to QRS pattern were noted. It was concluded that retrievers had a specific shape of QRS complex which must be considered when evaluating a patient suspected of having cardiac disease. However, amplitude and durations of different ECG waves in all the six leads were statistically not affected by gender or body weight.
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