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Articles by Muberra Uygun
Total Records ( 2 ) for Muberra Uygun
  Gulnur Kizilay and Muberra Uygun
  Diabetes mellitus causes some changes in urine quality and quantity. Therefore, we planned this study to explain how these changes affect the histological structures in the urinary bladder. We classified this experimental subjects under 4 Groups as follows; Group I: Control group, Group II: 60 mg kg-1 single dose of streptozotocin was administered intraperitoneally (i.p.), Group III: 40 mg kg-1 dose of streptozotocin i.p. was administered 5 days consecutively, Group IV: 150 mg kg-1 single dose of alloxan was administered i.p. We obtained the biopsy materials of tunica mucosa of the urinary bladder after 6 months, then we exposed these materials for observations with light and electron microscopy. In Group II, we observed a decrease in the number of urothelium layers, loss of dome shaped cells which were replaced with the intermediate layer cells. In Group II and especially in Group III, we observed an increase in the thickness of the epithelial and capillary basement membranes. In Group IV, we observed a repair process in urothelium. The increase in the thicknesses of the basement membranes were less than the other groups. After the 6 months of experimental period, the degeneration of tunica mucosa in Group III, which had the highest blood glucose levels, seems to be related to the complications of lasting diabetes. The mild degeneration of tunica mucosa in Group II and Group IV seems to be related to the insuline production which was caused by β cell regeneration or island cell adenoma and also these factors reduced the complications of diabetes seriously.
  Yesim Hulya Uz and Muberra Uygun
  The aim of this study was to investigate whether the antioxidant vitamin E provided morphological protection in the nephrotoxicity caused by Cyclosporin A (CsA). Twenty-five Sprague-Dawley male rats were divided into five groups, each consisting of five rats. One of them was the control group and four of them were the experiment group. CsA (5 mg kg-1 day-1) to the Group II, III and V, CsA plus vitamin E (5 mg kg-1 day-1) to the Group IV were administered intraperitoneally (i.p.) for 8 weeks. The kidney specimens of the Group I, II and IV were taken at the end of the 8th week. The kidney specimens of the Group III were taken at the end of 14th week after they had been kept for reversibility for 6 weeks. As for t he kidney specimens of the Group V, they were administered vitamin E ( 5 mg kg-1 day-1) for 6 weeks after the administration of CsA (5 mg kg-1 day-1) for 8 weeks and then were taken at the end of the 14th week. All of these kidney specimens were processed for light and electron microscopical examination. In the Group II, infiltration foci and increase of interstitial connective tissue were observed at the surrounding of vessels, especially in the corticomedullary region. The most obvious changes were encountered in the proximal tubules. These changes were seen as degeneration and regeneration. While the degeneration was seen as the thickening of basement membrane, loss of brush border, vacuolization, dilation of the smooth endoplasmic reticulum, increase in lysosomes in number and size, the proliferation of some of the scattered epithelial cells of the tubules formed the regeneration areas by causing the appearance of new tubules. No obvious regression was seen in the Group III and more or less the same changes as in the Group II were observed. As vitamin E inhibited the oxidative damage of CsA, the least damage occurred in the Group IV. Because of the release of CsA accumulated in tissues later giving it into the organism, more damage was observed in the Group V compared to Group IV. Therefore, using CsA and vitamin E simultaneously may keep the nephrotoxicity caused by CsA at a minimal level.
 
 
 
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