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Articles by Mostafa Saadat
Total Records ( 5 ) for Mostafa Saadat
  Mostafa Saadat
  Masjid-I-Sulaiman (MIS) (Khozestan province, South-West of Iran) is contaminated with subsurface of natural sour gas leakage. In the present report the possible effect of environmentally contamination with natural sour gas on mortality due to cancers and psychiatric disorders was investigated. Data concerning mortality in MIS and Khozestan province are compiled using reports from the Statistical Center of Khozestan province from 20th March 2000 to 19th March 2002. The mortality in the Izeh and Shoshtar, the nearest city to MIS and the Khozestan province (excluding MIS) were used as controls. To test the null hypothesis that the mortalities due to cancers and psychiatric disorders in MIS are equal to the control populations, the Chi-square test was used. Statistical analysis of data demonstrated that there were significant differences between MIS and Khozestan province for cancers (χ2 = 20.58, df = 1, p<0.00001) and psychiatric disorders (χ2 = 43.79, df = 1, p<0.00001) related mortalities. There were significant differences between MIS and Izeh for cancers (χ2 = 7.24, df = 1, p = 0.0071) and psychiatric disorders (χ2 = 17.88, df = 1, p = 0.00002) related mortalities. Also there were significant differences between MIS and Shoshtar for cancers (χ2 = 9.23, df = 1, p = 0.0023) and psychiatric disorders (χ2 = 9.80, df = 1, p = 0.0017) related mortalities. There was no difference between either Izeh or Shoshtar and Khozestan province for mortalities due to cancers and psychiatric disorders. Taken together, it is suggested that high level of sulfur compounds in MIS has some role(s) in the high mortality rates due to cancers and psychiatric disorders in MIS.
  Mostafa Saadat
  To evaluate the public health impact of association between prevalence of GSTM1 and GSTT1 null genotypes and age-standardized cancer mortality rate the present study, using data of 45 countries from five continents was done. Data of prevalence of GSTM1 and GSTT1 null genotypes was obtained from published articles in scientific journals. Data about the age-standardized mortality rates due to cancers (per 100,000 population) (for 2002) and total expenditure on health at international dollar rate per capita (for 2003) were obtained from the World Health Organization Web site In order to rule out the possible confounding effect of total expenditure on health per capita on the mortality rate, partial correlation analysis was carried out. After controlling the total expenditure on health per capita, significant positive correlation between prevalence of GSTM1 null genotype and age-standardized cancer mortality rate was observed (r = 0.301, df = 42, p = 0.047).
  Mostafa Saadat
  The cytogenetic effects of the Hypericum perforatum L. and Matricaria chamomilla L. extracts have been studied in cultured human lymphocytes. The extracts were prepared by perculation method using 70% ethanol as a solvent. The effects of hydroquinone and ethanol were also investigated as positive and negative controls, respectively. The cytogenetic abnormalities detected were dicentric chromosome, chromatid breaks and polyploidy. The Hypericum perforatum L. (at final concentration of 0.4 μg mL-1 hypercin) and Matricaria chamomilla L. (at final concentration of 50 μg mL-1 chamazulenel) extracts, significantly increased the frequency of abnormal metaphases (For extract of Hypericum perforatum L. OR = 6.04, 95% CI: 3.11-12.1; For extract of Matricaria chamomilla L. OR = 6.22, 95% CI: 3.21-12.2).
  Mostafa Saadat , Mohammad Masoudi and Zahra Zendehboody
  It is well known that many components of herbal products are mutagens. Because of increasing use of medical herbs, in the present study the genotoxicity of Gasterolan was investigated using cultured human lymphocytes and rat bone marrow. Gasterolan (Goldaru Company, Esfahan, Iran) is used as an antispasmodic, carminative and for spastic disorders of the gastrointestinal tract. The drug contains hydroalcoholic extracts of Foeniculum vulgare fruits, Matricaria chamomilla flowers and Mentha piperita. The cultured human lymphocytes were treated with 0.5 and 0.75% (v/v) of Gasterolan and 0.75% of ethanol for 14 h. Chromatid break was used as a marker for damage. Ethanol did not increase the frequency of chromatid break (Z = 0.0068, p = 0.948). The frequency of chromatid break is significantly increased in 0.5 (Z = 2.75, p = 0.006) and 0.75 (Z = 7.47, p<0.001) percent of Gasterolan. Considering that ethanol does not increase the frequency of chromatid break, the observed effect is probably due to some components present in the herbal product. Investigation of rat bone marrow metaphases show that chromatid breaks increased as a function of harvest time (from 2-8 days after beginning the treatment) (r = 0.998, df = 2, p = 0.002). More studies are necessary to find components that increased chromosomal aberrations.
  Mostafa Saadat and Maryam Ansari-Lari
  Published studies have confirming or refusing an association between either glutathione S-transferase T1 (GSTT1) or M1 (GSTM1) polymorphism and asthma risk. Therefore the present meta-analysis was done. Literature-based meta-analysis was supplemented by tabular data from investigators of all relevant studies of two GST polymorphism (GSTM1 and GSTT1) available before May 2006, with investigation of potential sources of heterogeneity. Included in the resent study were 14 studies, involving a total 2292 asthma patients and 5718 controls. We found substantial evidence of heterogeneity between the studies. Exclusion of two studies with lowest quality scores resulted in a dramatic decrease in heterogeneity. The overall OR of the asthma risk associated with GSTM1 null genotype was 1.20 (95% CI: 1.08-1.35). Stratifying the meta-analysis by age and smoking status of subjects, the pooled ORs for GSTM1 null genotype were 1.56 (95% CI: 1.25-1.94) in adults and 1.95 (95% CI: 1.21-3.13) in non-smokers. The GSTT1 null genotype was associated with asthma risk in non-smoker adults (OR = 2.06, 95% CI: 1.21-3.71). To investigate whether profile of GST genotypes are associated with the risk of the asthma, further analysis combining the GSTT1 and GSTM1 genotypes were also carried out. Subjects with null genotypes for both GSTM1 and GSTT1 were at a significant higher risk for developing 2 = 12.07, df = 1, p = 0.0005). Overall, our present meta-analysis revealed that the null genotypes of GSTM1 and GSTT1 are associated with risk of asthma in adults especially in non-smoker ones. It might be suggested that chronic smoking carries such a high dose of toxins into the body that overloads the capacity of either GSTM1 or GSTT1 detoxification system. It seems that the GSTM1 and GSTT1 lack their protective values against development of asthma in adults with positive history of smoking. Present results also suggested that there is an additive effect for GSTT1 and GSTM1 genotypes.
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