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Articles by Monireh Halimi
Total Records ( 7 ) for Monireh Halimi
  Monireh Halimi , Amir Vahedi and Ebrahim Kord Mostafapour
  Vascular Endothelial Growth Factor (VEGF) is a known contributor to angiogenesis in tumor growth. Its functions are numerous and include up-regulation of anti-apoptotic factors, vascular endothelial cell proliferation and migration and enhanced vascular permeability. This study aimed at evaluating association of VEGF expression with regional (axillary) lymph node metastasis in patients with breast Invasive Ductal Carcinoma (IDC). Paraffin-embedded specimens obtained from 80 female patients with breast IDC were immunohistochemically assessed in Imam Reza Teaching Centre in a 12 month period of time. These specimens were categorized into two groups based on presence or absence of axillary lymph node metastasis (n = 40 for each group). Status of the VEGF was compared between the two groups. Both groups were comparable for age and cancer laterality. Mean tumor size, as well as the percentage of cases with grade III cancer was significantly higher in the group with axillary metastasis. “Rich” expression of VEGF was documented in 40% of the cases with nodal involvement vs. 25% of the cases with nodal spare. There was no significant difference between the two groups with regard to the status of VEGF expression (p = 0.15). This difference was again insignificant after adjusting for tumor size and grade. In conclusion, there is apparently no significant association between severity of VEGF expression and axillary lymph node metastasis in patients with breast IDC.
  Effat Khodaeiani , Monireh Halimi and Amir Hagigi
  Both Acne vulgaris and infection with Helicobacter pylori (HP) are very prevalent all over the world. The objective of this study was to examine possible association between HP infection and various severities of Acne vulgaris. In this case-control study, 100 adolescents and young adults were recruited from two educational dermatological centers in Tabriz over a one-year period (2012-2013), including 25 normal subjects (controls) and 75 patients with Acne vulgaris (mild = 25, moderate = 25, severe = 25). Infection with HP was investigated using 13C-urea Breath Test (UBT). Serum level of immunoglobulin G (IgG) against HP was also measured in all the participants. All the groups were matched for their participants’ age and sex. The rate of HP infection was 56% in the control group, 60% in the cases with mild Acne vulgaris, 72% in the cases with moderate Acne vulgaris and 88% in the cases with severe Acne vulgaris. In terms of the rate of HP infection, there was no significant difference between the controls and the cases with mild Acne vulgaris (p = 0.77), nor between the controls and the patients with moderate Acne vulgaris (p = 0.24). The rate of HP infection, however, was significantly higher in the cases with severe Acne vulgaris comparing with the controls (p = 0.01). Mean serum level of IgG was also significantly higher in the same group (1.87±1.62 U vs. 2.98±1.29 U, p = 0.05). Based on the findings of the present study, a significant association was present between severe Acne vulgaris and HP infection. Further studies with larger sample sizes are recommended.
  Heidarali Esmaeili , Monireh Halimi and Amir Hagigi
  According to an old notion, the axis of “brain-gut-skin” plays a significant role in the pathogenesis of acne vulgaris. This study aimed to compare gastrointestinal dysfunction symptoms in patients with different severities of acne vulgaris with their normal counterparts. In this cross-sectional, case-control study, 120 adolescents and young adults were recruited from two teaching dermatological clinics over a one-year period (2012-2013). These participants were 30 normal subjects (controls), 30 patients with mild acne vulgaris, 30 patients with moderate acne vulgaris and 30 patients with severe acne vulgaris. Frequency of gastrointestinal dysfunction symptoms including halitosis, gastric reflux, abdominal bloating, abdominal discomfort, constipation and diarrhea was compared between the controls and the patients. Serum lipids profile was also compared between the patients and the controls. All the four studied groups were matched for their members’ age and sex. Controls and the cases with mild acne vulgaris were comparable in terms of the frequency of gastrointestinal symptoms. Frequencies of abdominal bloating (30% vs. 10%, p = 0.05) and constipation (36.7% vs. 13.3%, p = 0.04) were significantly higher in the group with moderate acne comparing with the controls. They were also significant more frequent in the patients with severe acne comparing with the controls (40%, p = 0.01 and 46.7%, p = 0.01, respectively). Comparing with the controls, serum lipids profile was significantly deranged only in the cases with severe acne vulgaris. This study showed that gastrointestinal dysfunction is associated with moderate-to-sever acne vulgaris. In addition, serum lipids profile may be abnormal only in severe acne vulgaris.
  Behrooz Shokouhi , Monireh Halimi and Amir Hagigi
  Since metabolic abnormalities are common in psoriasis, some investigators have suggested that the risk of Coronary Artery Disease (CAD) may be increased in psoriatic patients. The underlying causes of this connection, however, have not been examined. This study sought to investigate common risk factors of CAD in patients with psoriasis. In a retrospective, case-control setting, profiles of 89 patients with angiographically proven CAD were reviewed. These patients were 47 cases with psoriasis and 42 controls without psoriasis. Demographic data, overweight/obesity, family history of CAD, hypertension, diabetes mellitus, smoking, increased level of serum low-density lipoprotein (LDL) and triglyceride and decreased serum level of high-density lipoprotein (HDL) were outcome variables which were compared between the two groups. The case group was consisted of 33 males and 14 females with a mean age of 51.04±8.79 years. The controls were 29 males and 13 females with a mean age of 57.00±9.37 years. Patients in the case group were significantly younger (p = 0.003). Increased serum LDL (59.6 vs. 38.1%, p = 0.04) and increased serum triglyceride (66 vs. 31%, p = 0.001) were significantly higher in psoriatic patients than in controls. These differences, as well as for age, remained significant after logistic regression analysis. The two groups were comparable in terms of sex (p = 0.91), overweight/obesity (p = 0.54), family history of CAD (p = 0.86), hypertension (p = 0.42), diabetes mellitus (p=0.97), smoking (p=0.28) and decreased serum level of HDL (p = 0.65). In conclusion, this study showed that patients with both CAD and psoriasis are younger than those with CAD only. Abnormal lipid profile is probably an underlying cause of the increased risk of CAD in psoriasis.
  Monireh Halimi , Behrooz Shokouhi and Amir Hagigi
  Psoriasis is a very commonly seen inflammatory condition in skin clinics. It has been suggested that this disease is associated with metabolic disease, particularly abnormalities in serum lipid profile. This study sought to examine possible association between plaque-type psoriasis and some individual variables of metabolic syndrome. After being approved by an ethical committee, 53 patients with plaque-type psoriasis were recruited along with 55 age and sex-matched healthy individuals as controls. The status of smoking, alcohol consumption and lipid profile including abnormally increases serum total cholesterol, Low Density Lipoprotein (LDL) and triglyceride, hypertension, diabetes mellitus and overweight/obesity were compared between the two groups. The case group was consisted of 27 males and 26 females with a mean age of 47.89±8.09 years. The controls were 35 males and 20 females with a mean age of 48.38±7.46 years. Smoking (43.4 vs. 20%, p = 0.01), increased serum total cholesterol (43.4 vs. 14.5%, p = 0.001), increased serum LDL (34 vs. 12.7%, p = 0.01) and hypertriglyceridemia (43.4 vs. 12.7%, p<0.001) were significantly higher in patients than in controls. These differences remained significant after logistic regression analysis. The two groups were comparable in terms of age (p = 0.74), sex (p = 0.18), alcohol consumption (p = 0.56), overweight/obesity (p = 0.74), hypertension (p = 0.33) and diabetes mellitus (p = 0.60). In conclusion, this study showed a significant association between smoking and abnormal lipid profile with psoriasis. Screening/preventive programs are recommended in this regard.
  A. Vahedi , I. Lotfinia , R.B. Sad , Monireh Halimi and H. Baybordi
  This study aims at assessing the relation between hypoalbuminemia and inhospital mortality in patients with acute stroke. In this cross-sectional study, a total of 112 consecutively admitted patients with first acute stroke in Ahvaz Jundishapur Hospital were enrolled. All patients hospitalized for 7-9 days or expired in this period of time. Admission hypoalbuminemia (serum albumin<3.5 mg dL-1) as well as other prognostic factors were determined and compared between the two groups. One hundred and twelve patients, 74 males and 38 females with the mean age of 69.2±12.1 (66-79) years were enrolled. Twenty nine (25.9%) patients expired during the hospitalization. Totally, admission hypoal buminemia was present in 49 (43.8%) patients. 43% of the patients were Hypoalbuminemia. Frequency of patients with admission hypoalbuminemia and is chemic heart disease was significantly higher in the nonsurvivors (75.8- 32.5%, p = 0.001; 34.5 vs. 16.9%, p = 0.047, respectively). The mean Glasgow Coma Scale score was significantly lower in the nonsurvivors (8.1±1.8 vs. 9.4±0.5, p = 0.003). These three parameters remained significant in multivariate analysis. Sex, age, history of hypertension, diabetes mellitus, hypertriglyceridemia, hypercholesterolemia, anemia, heart failure and smoking habit, admission atrial fibrillation, ethnicity and stroke type were comparable between the two groups. In conclusion, hypoalbuminemia is an independent predictor of inhospital mortality in patients with acute stroke.
  Monireh Halimi , Sam Morshedi Asl , Mohammad Saeid Hejazi , Amirala Aghbali and Mohammad Esmaeil Hejazi
  The role of Human Papillomavirus (HPV) has been suspected in pathogenesis of various malignancies; however, the available data are not conclusive. This study aimed to determine and compare the frequency of HPV infection in oral and lung Squamous Cell Carcinoma (SCC) by a sensitive method. Sixty specimens of oral and lung SCC (30 cases each one) were reevaluated in Tabriz Imam Reza Centre in a 24 month period. Following genomic DNA extract, the Polymerase Chain Reaction (PCR) amplification was performed in presence of specific MY11 and MY09 primers for HPV infection. Three cervical specimens and a combination of PCR solution lacking DNA plus healthy persons' DNA samples were employed as positive and negative controls, respectively. The oral group was significantly older than the lung group (68.90 vs. 56.67 y, p<0.001) with more males in the latter (83.3 vs. 60%; p = 0.04). Percentages of HPV infection in the oral and lung groups were comparable (20 vs. 10%, respectively; p = 0.47). Majority of patients with HPV infection were older than 60 years (88.9%) or male (88.9%). In the oral group, all these cases were well differentiated and the majority was of lower lip origin (83.3%). In the lung group, 66.7% of these specimens were moderately differentiated and the origin was bronchus in all cases. In conclusion, the rate of HPV infection in lung and oral SCC samples is rather lower than the previous reports in the literature. This rate is apparently higher in the oral than the lung SCC specimens.
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