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Articles by Mohd Zaini Asmawi
Total Records ( 3 ) for Mohd Zaini Asmawi
  Fazlina Mustaffa , Zurina Hassan and Mohd Zaini Asmawi
  This study was designed to investigate the antidiabetic property of Cinnamomum iners leaves which were used traditionally to combat diabetes. Firstly, the antidiabetic activity of petroleum ether, chloroform, methanol and water extract of C. iners leaves was evaluated. Next, the potential extract which was the methanol extract was fractionated to obtain ethyl acetate, n-butanol, chloroform and aqueous fraction. The active chloroform fraction was subjected to subfractionation process to obtain subfraction 1 (SF 1) and subfraction 2 (SF 2). Cinnamomum iners leaves active portion (methanol extract, chloroform fraction and subfraction 1) was standardized using cinnamic aldehyde. The antidiabetic activity of standardized C. iners leaves was assessed by using Intra-Peritoneal Glucose Tolerance Test (IPGTT). The antidiabetic mechanism of active portion of C. iners leaves were also determined by measuring glucose absorption from the intestine. This study showed significant glucose tolerance effect of active portion of C. iners leaf after repeated oral administration in STZ-induced diabetic rats. The antidiabetic mechanism of subfraction 1 and chloroform fraction of C. iners leaf is by inhibiting glucose absorption from intestine.
  Fazlina Mustaffa , Zurina Hassan and Mohd Zaini Asmawi
  In this study the antioxidant activity of C. iners leaves standardized extract was evaluated. Cinnamomum iners leaves (methanol extract, chloroform fraction and subfraction 1) was standardized using cinnamic aldehyde. The phenolic and flavonoid content of C. iners leaves and cinnamic aldehyde were determined in this study. In addition, the antioxidant potential of C. iners leaves was evaluated using DPPH (2,2-Diphenyl-2-picryl-hydrazyl) free radical scavenging method, hydrogen peroxide decomposition study and reducing power assay. This study showed that C. iners leaves standardized extract showed promising antioxidant property.
  Hafiz Muhammad Irfan , Mohd Zaini Asmawi , Nurzalina Abdul Karim Khan and Amirin Sadikun
  Moringa oleifera is cognizant locally as mungai in Malaysia and commonly used traditionally. Therefore, the 14-day study was conducted on STZ-induced diabetic rats to evaluate the effect of 95% ethanolic extract of Moringa oleifera leaves on body weight, hyperglycemia and lipids. Group-I was negative diabetic control, received distilled water (10 ml/kg bw). Metformine (500 mg/kg bw) treated group-II was specified as positive control while group-III to VI received leaves extract with variable doses (1000, 500, 250, 125 mg/kg bw orally). In multiple dose experiment, the blood glucose and body weight monitoring was executed at day 0, 7 and 14 while in single dose at 0, 1, 3, 5 and 7 h. At the end of treatment, animals were sacrificed and blood was collected through cardiac puncture for lipid profile. The acute and sub-chronic treatment exhibited highly significant (p<0.01) fall in blood glucose at 500 and 1000 mg/kg dose and 25.8% decline in body weight was observed. The treated group also offered reduction in total cholesterol (p<0.01), triglycerides (p<0.05) and low density lipoprotein (p<0.01). It also appeared that by reducing the dose of extract, both the antihyperglycemic and loss of body weight decreases in treated groups. It can be recommended in obese diabetic patients to prevent macrovascular complication pertinent to body weight and lipids.
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