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Articles by Mohammed A. Ibrahim
Total Records ( 10 ) for Mohammed A. Ibrahim
  Mohammed A. Ibrahim
  .
  Farqad F.M. Saeed and Mohammed A. Ibrahim
  The aim of this study is to ascertain the influence of temperature on the bio-hydrogen productivity of marine green algae Chaetomorpha sp. GAF99 in sea water bioreactor system by utilizing multiple regression analysis. The biohydrogen production by green alga cultures was measured periodically at different incubation temperatures of active biohydrogen production phase to generate a model as well as surface response. The generated model {P = 26.81015e (-0.1[(Te-22.6)2+(Tm-24.7)2])} relates production of H2 (mL) as a function of temperature at two daily measurements (i.e., Tm, Te). The results revealed that the model can give significant correlation ship between biohydrogen production and temperature of incubation according to ANOVA statistical analysis based on F and p tests. The model and surface response curve obtained in this study showed clearly that the optimum biohydrogen production was recorded at the dark period at 23.2°C.
  Farqad F.M. Saeed and Mohammed A. Ibrahim
  Biohydrogen production by green algae is effected by environmental conditions. The aim of this study was to show the influence of pH on biohydrogen production by Chaetomorpha sp. GAF99, green alga isolated from Gulf of Aqaba, in seawater bioreactor under anaerobic condition. It was possible to generate a model {HP = 40.52896 e (-15x[(T(C)-24.8)2+(pH-8.18)2])} and building three dimensional plot in order to show the critical influence of various pH values on the biohydrogen production by Chaetomorpha sp. GAF99.The results revealed that the model can give significant relationship between biohydrogen production and pH according to ANOVA statistical analysis based on F and P-tests. The model and three dimensional plot obtained in this study showed clearly that the optimum biohydrogen production was recorded at pH values in the range of 8.2 to 8.7.
  Mohammed A. Ibrahim and Farqad F.M. Saeed
  Green algae are promising source of various types of biofuels and many are capable to catalyze production of hydrogen. In the present work isolation and characterization of green alga collected from Jordan’s coastal part of Gulf of Aqaba are reported. Morphological details of the purified green alga GAF99 indicated it belongs to genus Chaetomorpha. Potential of the alga for hydrogen production in sea water bioreactor was investigated under various environmental conditions. Hydrogen productivity of Chaetomorpha sp. GAF99 was influenced by temperature and light. The main algal capability of hydrogen production occurs during dark period at 23±1°C and it is decreased drastically at higher temperature. Gas chromatography analysis of gaseous mixture obtained under different environmental conditions showed that the percentages of hydrogen gas were in the range 97.767 -99.494. The reported results might indicate that green alga GAF99 has a promising potential for hydrogen production under specific environmental conditions.
  Mohammed A. Ibrahim , Noha Saleh , Esmael Archoukieh , Haithum W. Al-Obaide , Mohannad M. Al-Obaidi and Harun M. Said
  Molecular genetic studies suggested that genetic instabilities of genomic DNA are implicated in the pathogenesis of cancers. In this study the molecular genomic polymorphism of acute lymphoblastic leukemia was analyzed by 23 arbitrary primers of decamer oligonucleotides to investigate the genetic correlation by cluster tree analysis. Ten primers were able to amplify genomic DNA of leukemia patients, but varied in their ability to detect genomic DNA instability. One of amplifying primers showed novel pattern of amplified DNA fragments. It amplified DNA fragment (3.162 kbp) in normal individuals but was absent in 77.8% of patients, whereas other amplified DNA fragment (0.98 kbp) was absent in normal individuals but it was present in 55.6% of patients. Moreover, dissimilarity matrix analysis of amplified DNA fragments provided genetic relatedness among genomic DNA of patients.
  Mohammed A. Ibrahim
  DNA methylation is one of three epigenetic mechanisms which has seen increasing interest among cancer researchers, as changes in DNA methylation have emerged as one of the most consistent molecular aberrations in various neoplasms. Aberration of DNA methylation have been identified in the global genomic DNA (hyper or hypo methylation) or within CpG islands in promoter regions of tumor suppressor genes. Several types of bacteria which cause chronic infections are associated with cancer development and chronic infection of Helicobacter pylori might give rise to changes in pattern of DNA methylation. Recent discoveries are giving evidence in the involvement of aberration in DNA methylation in conferring resistance to antitumor agents, and efforts of molecular biologists are directed to overcome this problem by introducing new epigenomic drugs which reform DNA methylation, and help in tumor therapy. Another interesting prospective of current research in DNA methylation is the possibility of development molecular markers for early detection of tumors. The objectives of this article are to review various recent progress of DNA methylation in cancer research.
  Mohammed A. Ibrahim , Kalkunte S. Srivenugopal and Kakil Ibrahim Rasul
  Active platinum compounds have important applications in treatment of number of malignant tumors and are used in the treatment of lung, ovarian, head and neck, testicular, cervical, colorectal and relapsed lymphoma. The success of platinum drugs in treatment of various types of cancers has been challenged by problems of intrinsic and acquired resistance. Biochemical and genetical studies have confirmed that platinum resistance is multifactorial and includes changes in drug transport leading to decreased drug accumulation, increased drug inactivation or detoxification, changes in DNA repair and damage bypass and alterations in the apoptotic cell death pathways. Molecular studies have revealed that genetic factors and epigenetic mechanisms are linked to platinum resistance. Proteomimetics might prove to be clinically useful as new anticancer agents capable of overcoming apoptosis resistance. The study summarizes the current and future trends of novel molecular discoveries which will find new ways to combat platinum resistance and permit the designing of patient-specific pharmacological interventions to circumvent platinum resistance and increase the drug efficacy.
  Mohammed A. Ibrahim and Adil Makkiya
  There is increasing evidence on the association of chronic bacterial infections with development of various types of cancers. Bacterial infections are involved in the processes and mechanisms leading to chronic inflammations, these are shown to cause molecular genomic damage and alterations which lead to transformation of normal cells to malignant cells. Moreover carcinogenic bacterial metabolites and toxins were found associated with development of various types of cancers. Furthermore recent findings are relating specific bacterial infections and inflammations with aberration of genomic DNA methylation. This article reviews various aspects which link chronic bacterial infections with chronic inflammations, development of cancers and their influence on aberration of genomic DNA methylation.
  Mohammed A. Ibrahim , N. Saleh , Khalida M. Mousawy , N. Al-Hmoud , E. Archoukieh , Haithum W. Al-Obaide and Mohannad M. Al-Obaidi
  In this study the molecular genomic polymorphism of age related acute myeloid leukemia was analyzed by twenty one arbitrary primers of decamer oligonucleotides to investigate the genetic polymorphisms. Two categories of RAPD primers were identified, according to their ability to amplify genomic DNA. Thirteen primers were found unable to amplify genomic DNA of acute myeloid leukemia patients. On the other hand, eight primers were able to amplify genomic DNA and were divided into two subgroups, first group showed monomorphic DNA fragments, whereas the second one gave polymorphic bands. One of the polymorphic amplifying primers showed unique patterns of amplified DNA fragments in the genomic DNA of age related acute myeloid leukemia.
  Mohammed A. Ibrahim
  Recent advances in molecular genomic analysis showed the possibility of resolving the unexplained mysteries and problems of various biological phenomena. DNA methylation is one of three molecular epigenomic mechanisms involved in controlling gene expression during the process of cellular differentiation, development and aging. This genomic phenomenon has become of great interest in applied research of molecular medicine for its participation in development of various diseases. There is much evidence of possible connection between genomic DNA methylation profiles and psychiatric disorders. Recent studies have demonstrated possible role of DNA methylation in schizophrenia, depression, suicide and bipolar disorder. Aberrations in DNA methylation of several promoter regions of genes have been identified in the genomes of patients with psychiatric disorders. The aim of this effort is to review research work and looking into possible link between abnormal DNA methylation in genomic DNA and psychiatric disorders.
 
 
 
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