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Articles by Mohammad Shokrzadeh
Total Records ( 3 ) for Mohammad Shokrzadeh
  Monireh Jahani , Mohammad Shokrzadeh , Zeinab Vafaei-Pour , Ehsan Zamani and Fatemeh Shaki
  Background: Diabetes is the growing health problem worldwide and increasing diabetes prevalence has been reported in the most countries. Several mechanisms are suggested for diabetic nephropathy that oxidative stress is the most important one. In this study efficiency of nanoceria (a potent antioxidant) was evaluated for attenuation of nephropathy and oxidative stress diabetic mice. Materials and Methods: Mice were divided into five groups, each comprising of 6 mouse, diabetes was induced by a single dose of streptozocin (65 mg kg–1 b.wt., IP) diluted in citrate buffer (pH = 4.6). One week after streptozocin administration, blood glucose was taken using a glucose oxidase method and the mice whose blood glucose values were above 200 mg dL–1 accepted as diabetic. All animals were anaesthetized and blood was collected for BUN and creatinine levels assessment in plasma and kidney tissue were excised at 4°C and oxidative stress and pathological changes were assayed. Results: The significant increase in BUN and creatinine in plasma in diabetic mice accompanied by pathological changes in kidney tissue confirmed the nephropathy in diabetic mice. Also, increased in reactive oxygen species formation, lipid peroxidation, glutathione oxidation and protein carbonyl concentration were observed in the kidney tissue of diabetic mice. Nanoceria treatment significantly (p<0.05) inhibited oxidative damage in kidney tissue and pathological changes in diabetic mice. Conclusion: This study showed that nanoceria has protective effects against diabetic nephropathy via inhibition of oxidative stress pathway. Therefore, nanoceria can be considered as a potential complementary therapy beside other blood glucose-lowering drugs for amelioration of diabetic complications.
  Mohammad Ali Ebrahimzadeh , Mohammad Shokrzadeh and Ahmad Ramezani
  The main goal of this study was to compare the utilization of antibiotics in different wards of a university hospital. Consumption of antibacterial drugs rose dramatically during years 2000-2005 in Iran. Data collected during first half of year 2000 and 2005 in Emam University Hospital in city of Sari in Iran, showed use of antibiotics jumped from 95.4 DBDs (Defined Daily Doses per patient`s bed-days) to 124 DBDs. Distribution of different class of anti-microbial showed highest increase in use of vancomycin with 28.4 folds and clindamycin with 4.8 fold. Use of cotrimoxazole, aminoglycosides and tetracyclines remained fairly unchanged during this period. However, during the same period, consumption of penicillin G, aminopenicillins and cloxacillin dropped 10.3, 3.8 and 3 fold, respectively. Among university hospital departments, oncology ward followed by ICU and general surgery consumed the most antibacterial agents in year 2000. In year 2005, ICU ward followed by gynecology, oncology and orthopedic were among the University Hospital Departments with highest consumption of antibiotics. The most highly used antibiotics in year 2000 were cefazolin followed by ampicillin, ceftizoxime and gentamicin. In year 2005, cefazolin, ceftriaoxone, gentamicin and ciprofloxacin were the most prescribed antibiotics. Injectable antibiotics accounted for 51.8 and 79.4% of total DBDs in first half of years 2000 and 2005, respectively. The bulk of prescription (90% of total DBDs) was made up of 13 out of 32 total antibiotic types in 2000 and 11 out of 29 total antibiotics types in 2005. Comparing with similar hospitals in other countries, data presented show a dramatic increase in antibiotics prescribed by physician in Emam University Hospital.
  Mohammad Shokrzadeh , Sepideh Shobi , Hossein Attar , Sahel Shayegan , Sakineh Sadat Hosseini Payam and Faezeh Ghorbani
  Diazinon, a commonly used organophosphorus pesticide, has been widely used throughout the world in agriculture and horticulture to control insects that feed on crops, ornamentals, lawns, fruits, vegetables and other food products. The toxicity of the DZN causes adverse effects on many organs. The purpose of this study was to examine the protective effect of vitamins A, E and C on liver enzymes alanine transaminase (ALT), Aspartate aminotransferase (AST) and Lactate Dehydrogenase (LDH) in rats exposed to diazinon. In this study, male wistar rats were randomly divided into 10 different groups. The groups were administered normal saline, soybean oil (as the solvent for diazinon and fat-soluble vitamins), diazinon, (30 mg kg-1), vitamins E, C and A (100, 500 mg kg-1 and 400 IU kg-1, respectively) and a combination of diazinon with the same dose of each vitamin intraperitoneally i.p.daily for 14 days. Seven days after the final injection, the animals were anesthetized and blood samples were taken. The photometric method was used to measure the activity of the enzymes. The activities of ALT and AST in the diazinon group were significantly higher than that observed in the control group; however, the diazinon/vitamin E, A, C group displayed significant reduction in ALT and AST activities compared to the diazinon group. The lowest level of LDH enzyme activity was observed in the dazinon/vitamin C group and this was statistically lower than the diazinon group. The results of this study revealed that vitamin E, A and C have a potent protective effect against diazinon-induced hepatotoxicity in rats, which may be due to the scavenging of free radicals and increased antioxidant status.
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