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Articles by Mohammad SADEGHI
Total Records ( 3 ) for Mohammad SADEGHI
  Mohammad SADEGHI and Hossein HOSSEINZADEH
  Superabsorbent polymers based on starch (St) and polyacrylonitrile (PAN) were prepared by alkaline hydrolysis of the physical mixture of St and PAN in aqueous solution. The nitrile groups of PAN were completely converted to a mixture of hydrophilic carboxamide and carboxylate groups during alkaline hydrolysis, followed by in situ cross-linking of the PAN chains by the alkoxide ions of St. A proposed mechanism for hydrogel formation was suggested and the structure of the product was established using FTIR spectroscopy. Moreover, morphology of the samples was examined by scanning electron microscopy. The factors that influenced the swelling capacity of the hydrogels were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. Furthermore, the salt sensitivity of the hydrogels was investigated in different saline solutions. The pH-reversibility and on-off switching properties of the hydrogels make the intelligent polymers good candidates for consideration as potential carriers of bioactive agents. Finally, the swelling and de-swelling kinetics behaviors of the hydrogels were preliminarily investigated as well.
  Mohammad SADEGHI and Hossein HOSSEINZADEH
  Superabsorbent polymers are obtained by the graft copolymerization of 2-acrylamido-2-methylpropanesul- fonic acid (AMPS) monomer onto collagen, using ammonium persulfate as a free radical initiator in the presence of methylene bisacrylamide as a crosslinker. Infrared spectroscopy and TGA thermal analysis were carried out to confirm the chemical structure of the hydrogel. Moreover, morphology of the samples was examined by scanning electron microscopy (SEM). The effect of reaction variables on swelling capacity was investigated to achieve a hydrogel with improved water absorbency. Under the optimized conditions concluded, maximum capacity of swelling in distilled water was found to be 268 g/g. The swelling ratio in various salt solutions was investigated in detail. Since this hydrogel exhibited a very high absorptivity in saline, it may be referred to as a low salt-sensitive superabsorbent. The collagen-g-AMPS hydrogel also showed cation exchange properties. The swelling kinetics of the synthesized hydrogels with various particle sizes was also preliminarily investigated.
  Mohammad SADEGHI
  The present work focused on the design of a drug delivery system (DDS) based on pH-sensitive hydrogel. The hydrogels were prepared via graft copolymerization of mixtures of acrylic acid (AA) and 2-hydroxy ethyl methacrylate (HEMA) onto starch backbones by a free radical polymerization technique. Sodium bicarbonate (NaHCO3) was added to function as a foaming agent under acidic conditions, rendering the hydrogels to be porous. The porous structure of the hydrogel was essential in this system to yield a large surface area so that 5-fluorouracil (5-FU) release could be facilitated. The hydrogel, thus prepared, possessed a porous structure as determined by scanning electron microscopy. The water absorbency of the hydrogels was measured in solutions with pH levels ranging from 1 to 13. The starch-based hydrogel exhibited a pH-responsiveness character such that a swelling-deswelling pulsatile behavior was recorded at pH levels of 2 and 7. Using the drug 5-FU as a model molecule, the in vitro controlled drug-release behaviors of these hydrogels were investigated. The results indicate that the main parameter affecting the drug-release behavior of hydrogels is the pH of the solution. The release rate of 5-FU from hydrogel at pH 7.4 was faster than that at pH 1.2 due to the shrinkage of the hydrogel at pH 1.2. These results suggest that a porous hydrogel could potentially be a useful local delivery system to release drugs, primarily at a specific site of body.
 
 
 
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