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Articles by Mohammad Rahbani
Total Records ( 2 ) for Mohammad Rahbani
  Mohammad Rahbani , Daryoush Mohajeri , Ali Rezaie and Mehrdad Nazeri
  The negative impact of diabetes on the retinal, renal, nervous and cardiovascular systems is well recognized yet little is known about the effect of this disease on the liver. Oxidative stress is currently suggested as a mechanism underlying diabetes mellitus complications. The present study was designed to assess the liver injury as a complication of diabetes mellitus and to evaluate the hepaoprotective properties of ethanolic extract of Saffron (dried stigmas of Crocus sativus L.) in streptozotocin-induced diabetes in rats. Aminotransferases, Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were measured to determine the concentration of intracellular hepatic enzymes that have leaked into the circulation and serve as a marker of hepatocyte injury. Alkaline Phosphatase (ALP) and bilirubin were measured to assess biliary function. Albumin was measured to reflect liver synthetic function. The lipid peroxidation product, Malondialdehyde (MDA) and reduced Glutathione (GSH) content was measured to assess free radical activity in the liver tissues. The enzymatic activities of Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were measured as indicators of antioxidation in liver tissue. Moreover, histopathological observations were assayed at the degree of hepatic injury. For this purpose, male Wistar rats were made diabetic with a single injection of STZ (75 mg kg-1 i.p.). Rats were randomly separated into four groups, each containing 10 animals: Group 1, healthy control rats; Group 2 non-diabetic rats were treated with 40 mg kg-1 b.w./day intraperitoneal (i.p.) injection of Saffron extract; Group 3, diabetic rats; Group 4, diabetic rats were treated with saffron extract (40 mg kg-1 b.w./day, i.p.) for a period of 8 weeks. At the end of the experiment, MDA contents of the liver tissue and serum levels of ALT, AST, AP and bilirubin in Groups 3 were found to be significantly increased as compared to Group 1 (p<0.05) and these serum biomarkers of hepatic injury and liver MDA level in Group 4 were significantly decreased as compared to Group 3 (p<0.05). The GSH, SOD, CAT and GSH-Px contents of the liver and serum albumin level in Group 3 was significantly decreased as compared to Group 1 (p<0.05) and were found to be significantly increased in Group 4 as compared to Groups 3 (p<0.05). Histopathological changes were in agreement with biochemical findings. Based on these findings, it is presumed that ethanolic extract of C. sativus L. stigma may have the hepatoprotective effect in experimentally induced diabetic rats. Researchers suggest that saffron extract has beneficial effects on antioxidant defence of diabetic liver tissue.
  Mohammad Noori , Masoud Darabi , Ali Rahimipour , Mohammad Rahbani , Naser Aslan Abadi , Maryam Darabi and Keyhan Ghatrehsamani
 

Background

The phospholipid fatty acid content of high-density lipoprotein (HDL) partially reflects that of the diet and has been reported to be associated with several important biological functions that might serve as risk markers for coronary heart disease.

Objective

To investigate whether fatty acid composition of HDL phospholipids correlates with angiographically documented coronary artery disease (CAD).

Methods

The population included 212 patients who underwent clinically indicated coronary angiography. The patients were classified with significantly diseased arteries (SDA) if one or more coronary arteries had a stenosis >50% and with minimally diseased arteries (MDA) if there was no significant stenosis (<40%) in any artery. The severity of CAD was expressed by the number of affected vessels. The fatty acid composition of HDL phospholipids was determined by gas liquid chromatography. Multivariate analyses were used to test the independence of associations between the presence and severity of CAD as outcome variables and fatty acid composition of HDL phospholipids.

Results

Patients with SDA showed significantly lower levels of linoleic acid (P = .041), eicosapentaenoic acid (EPA) (P = .027), and docosahexaenoic acid (DHA) (P = .026) than patients with MDA in univariate analyses. The association of linoleic acid (odds ratio [OR] .90, P < .05), EPA (OR, 0.41, P < .02), and DHA (OR, 0.48, P < .02) remained statistically significant in the multivariate analyses. The content of EPA (β = −0.23, P < .01) and DHA (β = −0.17, P < .05) remained inversely significantly associated with the severity of CAD.

Conclusions

This study shows that polyunsaturated fatty acids, including EPA and DHA content of HDL particles, are independently associated with the presence and severity of angiographically documented CAD.

 
 
 
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