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Articles by Mohammad Ayman Salkini
Total Records ( 2 ) for Mohammad Ayman Salkini
  Hasan Soliman Yusufoglu , Gamal Abdulhakim Soliman , Ahmed Ibrahim Foudah , Maged Saad Abdulkader , Mohd Nazam Ansari , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Silene villosa (Family-Caryophyllaceae) is used traditionally in different part of Asian continents for the treatment of various illnesses. Recently, S. villosa has been tested and confirmed for anti-inflammatory and antioxidant activities. Therefore, the present study was carried out to evaluate cardiac and renal protective effects of S. villosa extract (SVE) against CCl4-induced toxicity. Materials and Methods: The herbs of S. villosa were collected, authenticated, coarsely powdered and extracted in Methanol using percolation method. Wistar albino rats (≈200 g) of either sex were randomly divided into five groups. Group I (normal control) and Group II (toxic control) received normal saline (1 mL/100 g, p.o.) for 7 days. Groups III (positive control), IV and V (Test groups) were received Silymarin (10 mg kg–1, p.o.), SVE at doses of 250 and 500 mg kg–1, p.o., respectively for 7 days. On the 8th day, except normal group (Group I), all Groups were administered with CCl4 (1.0 mL kg–1, i.p). After 24 h of CCl4 administration, the serum cardiac function parameters such as (LDH, CK and Albumin) and the serum renal function parameters such as creatinine, urea and uric acid, electrolytes and tissue total proteins were measured as a marker of cardiac and renal toxicity. The cardiac and renal tissue parameters such MDA and NP-SH were measured for the in vivo antioxidant activities. Further, the biochemical studies were followed by histopathological studies of heart and kidney tissues. Results: The treatment of CCl4 in rats, significantly altered the cardiac and kidney function test limitation. Administration of SVE at two different doses of 250 and 500 mg kg–1 with CCl4 showed a significant (p<0.01-0.001) protective ability against CCl4 intoxication by repairing the cardiac and kidney function abnormalities. The protective ability of SVE was further confirmed by the histological study of cardiac and renal tissues. Conclusion: The results led us to the conclusion that SVE ameliorate the cardiac and renal dysfunction.
  Hasan S. Yusufoglu , Gamal A. Soliman , Ahmed I. Foudah , Maged S. Abdulkader , Hossny A. El-Banna , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Arnebia hispidissima (F. Boraginaceae) has been found to have cardiac and febrifuge properties. It has long been used in traditional system of medicine for the treatment of heart ailments, headache and fever. This study aimed to investigate the protective effect of Arnebia hispidissima extract (AHE) on carbon tetrachloride (CCl4)-induced cardiotoxicity and nephrotoxicity. Materials and Methods: Adult rats were divided into five groups and medicated as follows: (1) The control group received the vehicles (olive oil; 1 mL kg–1, i.p.+3% Tween 80; 1 mL kg–1, p.o.). (2) CCl4 group of animals was administered with 20% CCl4 in olive oil (1 mL kg–1, p.o.). (3) Silymarin group was co-administered with CCl4 plus silymarin (50 mg kg–1, p.o.). (4) CCl4 plus AHE (200 mg kg–1, p.o.). (5) CCl4 plus AHE (400 mg kg–1, p.o). Rats received vehicle, CCl4, silymarin or AHE twice a week for 8 weeks. Serum AST (aspartate transaminase), LDH (lactate dehydrogenase), CK (creatine kinase), CK-MB (creatine kinase-MB isoenzyme) and cTnI (cardiac troponin) were measured to assess the heart damage markers. Serum levels of creatinine, urea, uric acid and BUN (blood urea nitrogen) were measured as markers of the renal function. Markers of oxidative stress in the cardiac and renal tissues were estimated by determining the levels of SOD (superoxide dismutase), GPx (glutathione peroxidase), CAT (catalase), GSH (reduced glutathione) and MDA (malondialdehyde). Heart and kidney tissues were investigated for histopathological changes. Results: Administration of CCl4 significantly increased the levels of cardiac and renal damage markers. Co-administration of CCl4 plus AHE significantly relieved the adverse effect of CCl4 in rat and reduced the increased serum levels of cardiac and renal damage markers. AHE compensated the deficits in the antioxidant defense mechanisms (SOD, GPx and CAT) and suppressed LPO (lipid peroxidation) in rat heart and kidney resulting from CCl4 administration. Moreover, histopathological changes induced with CCl4 in heart and kidney tissues of rat were also reduced with the co-administration of AHE. Conclusion: In this study, we have found that oral administration of AHE prevented CCl4-induced cardio- and nephrotoxicity by accelerating heart and kidney antioxidant defense mechanisms and down regulating the LPO near to the normal levels.
 
 
 
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