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Articles by Mohammad Abdi
Total Records ( 2 ) for Mohammad Abdi
  Seyed Abdolhakim Hosseini , Mehdi Mahmoodi , Mohammad Saeed Hakhamaneshi , Shadi Hosseini , Mohammad Abdi , Sadegh Zarei , Seyed-Mostafa Hosseini-Zijoud and Javad Hosseini
  Hyperglycemia in diabetes causes glycosylation of the body proteins that leads to a change in their conformation and function. In this study the influence of the Aloe vera's extracts on the inhibition of the Albumin glycosylation reaction and on the breaking the bond between Albumin and glucose was surveyed in vitro. The influence of Aloe vera at 0.1, 0.2, 0.5 and 1 g dL-1 concentrations in two states; influence on the inhibition reaction of Albumin glycosylation and influence on the bond breaking between Albumin and glucose was surveyed in vitro. The rate of glycosylation was measured by thiobarbituric acid (TBA) and p<0.05 was considered as significant Level. Aloe vera's extract can inhibit significantly the Albumin glycosylation reaction in all concentrations except in 1 g dL-1 concentration and it has maximum inhibitory effect in 0.1 g dL-1 concentration (p<0.05) and the rate of this inhibition was time dependent. Additionally, it could break the Albumin-glucose bond and the maximum effect was seen with 0.1 g dL-1 concentration (p<0.05). The results demonstrate that Aloe vera inhibits the glycosylation of the Albumin and also break the Albumin-glucose bond down, thus it has a hypoglycemic effect.
  Mohammad Abdi , Bayazid Ghaderi , Sabrieh Amini , Arghavan Baban , Sonya Najafpour , Sahar Naderi and Shamisa Pourdad
  One of the most important polymorphism in p53 gene occurs in codon 73 of exon 4. Individuals who have Arg/Arg allele may have an increase risk for progress of cancer. The present study was aimed to develop a rapid, inexpensive and simple high resolution melting curve analysis method to distinguish different genotype of codon 72 p53. This study was performed on 167 patients with four common cancers in Kurdistan. High resolution melt analysis of PCR products revealed different allele of codon 72 p53 gene. Genotyping by high resolution melt analysis was verified by DNA sequencing. The samples were categorized as Arg/Arg (31%), Arg/Pro (44%) and Pro/Pro (25%) in four cancer types. Patients with colorectal cancer had the highest frequency of Arg/Arg polymorphism (65%). High resolution melting analysis was completely compatible with sequencing results. The results indicate individuals with Arg/Arg allele of codon 72 p53 gene have an increased risk for development of cancer in Kurd ethnicity. In addition high resolution melting analysis is useful for rapid differentiation of p53 alleles and can be used for diagnostic purposes directly from clinical samples, as well as epidemiological studies.
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