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Articles by Mohammad Sharifzadeh
Total Records ( 2 ) for Mohammad Sharifzadeh
  Mohammad Sharifzadeh , Kurdistan Sharifzadeh , Mahnaz Khanavi , Abbas Hadjiakhoondi and Abbas Shafiee
  The aim of this study was to evaluate the anti-inflammatory activities of total methanolic extracts isolated from aerial parts of Stachys persica and Stachys setifera. The anti-inflammatory properties of the extracts were assessed by using two well-characterized inflammatory models, carrageenan-induced paw edema and formalin test in rats and mice. Intraperitoneal injections of the extracts 60 min before carrageenan injection caused significant inhibition on carrageenan-induced paw edema over the dose range 50-200 mg kg-1. The extract of Stachys persica showed more inhibitory effect especially with higher doses (100 and 200 mg kg-1). In the formalin test, intraperitoneal injections of different doses (50, 100 and 200 mg kg-1) of either Stachys persica or Stachys setifera 30 min before formalin injection did not show any inhibitory effects in the first phase (0-10 min) of the formalin-induced pain, but all three doses of the extracts revealed a significant (p<0.01) blockade of the second phase (20-30 min) nociception. The anti-inflammatory properties of both extracts were comparable with indomethacin as a potent non-steroidal anti-inflammatory drug. In conclusion, the present findings provide further evidences for inhibitory effects of Stachys persica and Stachys setifera in inflammatory processes via possible interactions with cyclooxygenase products.
  Naghmeh Hajarolasvadi , Mohammad J. Zamani, , Parisa Sarkhail , Reza Khorasani , Masoomeh Mohajer , Gholamreza Amin , Abbas Shafiee , Mohammad Sharifzadeh and Mohammad Abdollahi
  The objective of the present study was to evaluate the anti-inflammatory and analgesic activities of the crude and fractioned extracts (ether, ethyl acetate, n-butanol and water) of Phlomis anisodonta (Lamiaceae) in the models of carrageenan-induced paw edema and acetic acid-induced writhing in mice. Dried powdered material from the aerial parts of Phlomis anisodonta was extracted with methanol (80%) twice. The methanol extract was separated into four fractions: after drying the methanol extract, the solid residue was dissolved in water and the water-soluble portion was successively partitioned to produce the above-mentioned fractions. The total extract, ether fraction and ethyl acetate fractions significantly reduced the number of writhings compared to the control group. Water and n-butanol fractions showed no analgesic activity. Neither the total extract nor four fractions were more effective than indomethacin in acetic acid-induced test. In carrageenan-induced inflammation test, only water and ethyl acetate fractions showed antiinflammatory activity compared to the control group. The total extract, n-butanol and ether fractions showed no antiinflammatory activity. Neither the total extract nor four fractions were more effective than indomethacin. Different types of glycosides found in the genus Phlomis could be responsible for observed effects. Variations in antiinflammatory and analgesic effects of different fractions of this plant might be attributed to the fact that different fractions of P. anisodonta contain active compounds in variable ratios and activities. A comprehensive analysis for determination and quantification of these compounds is required).
 
 
 
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