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Articles by Mohammad Saeid Hejazi
Total Records ( 2 ) for Mohammad Saeid Hejazi
  Mohammad Saeid Hejazi , Reza Ghotaslou , Majid Farshdoosty Hagh and Yashar Mohammadzadeh Sadigh
  A study was conducted on patients with Hepatitis C virus (HCV) infection, to identify HCV genotypes in Northwest Iran. Sera from 50 patients with HCV infections were selected to study the HCV genotype in Northwest of Iran. We employed an improved and simplified method of genotyping based on PCR with genotype-specific primers deduced from the core gene. HCV RNA was detected in 28 cases by RT-PCR. Of 28 HCV isolates, 20 (71.4%) were typed as genotype 1a, 4 isolates (14.2%) 1b, 2 cases (7.1%) 2a and 2 HCV sera were not typed by this assay. Genotype 1 was detected in a significant majority of HCV infected patients in this area.
  Monireh Halimi , Sam Morshedi Asl , Mohammad Saeid Hejazi , Amirala Aghbali and Mohammad Esmaeil Hejazi
  The role of Human Papillomavirus (HPV) has been suspected in pathogenesis of various malignancies; however, the available data are not conclusive. This study aimed to determine and compare the frequency of HPV infection in oral and lung Squamous Cell Carcinoma (SCC) by a sensitive method. Sixty specimens of oral and lung SCC (30 cases each one) were reevaluated in Tabriz Imam Reza Centre in a 24 month period. Following genomic DNA extract, the Polymerase Chain Reaction (PCR) amplification was performed in presence of specific MY11 and MY09 primers for HPV infection. Three cervical specimens and a combination of PCR solution lacking DNA plus healthy persons' DNA samples were employed as positive and negative controls, respectively. The oral group was significantly older than the lung group (68.90 vs. 56.67 y, p<0.001) with more males in the latter (83.3 vs. 60%; p = 0.04). Percentages of HPV infection in the oral and lung groups were comparable (20 vs. 10%, respectively; p = 0.47). Majority of patients with HPV infection were older than 60 years (88.9%) or male (88.9%). In the oral group, all these cases were well differentiated and the majority was of lower lip origin (83.3%). In the lung group, 66.7% of these specimens were moderately differentiated and the origin was bronchus in all cases. In conclusion, the rate of HPV infection in lung and oral SCC samples is rather lower than the previous reports in the literature. This rate is apparently higher in the oral than the lung SCC specimens.
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