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Articles by Mohammad Reza Fazeli
Total Records ( 2 ) for Mohammad Reza Fazeli
  Arash Mahboubi , Tahereh Hallaj Shooshtari , Mohammad Reza Fazeli , Rasoul Dinarvand , Nasrin Samadi , Mohammad Sharifzadeh , Houshmand Ilka , Saeed Azadi and Mahboubeh Valadkhani
  In this study the immunogenicity of four commercially available hepatitis B recombinant vaccines in Iran was compared. The vaccines included both the well known brand of Engerix-B and three biosimilars of Heberbiovac HB, Euvax B and Hepavax-Gene. Vaccines were administered intra-peritoneally (i.p) to Balb/C mice and the immune responses were evaluated by comparing the Geometric Mean Titer (GMT), the rate of seroconversion, seroprotection, ED50 as well as the relative potency of the vaccines. The GMT (mIU mL-1) obtained for Heberbiovac-HB was at least six folds of the other vaccines while its ED50 (ng) was also the lowest among the tested formulations. Similar results were obtained when the seroconversion and seroprotection of Heberbiovac-HB was compared to the others. The relative potency of Heberbiovac-HB was 30.13 (μg dose-1) which was well above the figures obtained for other vaccines. The results of immunogenicity markers in Balb/C mice of Heberbiovac-HB, a biosimilars hepatitis B vaccine in Iranian market was well above the well-known brand of Engerix-B but those figures obtained for other biogenerics were far behind those of Engerix-B. These results tend to suggest the important role of post marketing surveillance studies conducted by the national regulatory authorities in selecting the right products in national immunization programs.
  Ebtehaj Pishva , Nazila Hassannia , Mohammad Reza Fazeli , Asghar Havaee , Hossein Jamalifar , Mearaj Pour Hossein , Hassan Shojaee and Mojtaba Akbari
  It is obvious that some of resident gastrointestinal bacterial flora represented by Lactobacilli have protective role in pathogenic infections. There are many examples of probiotic effect of Lactic Acid bacteria on enteropathgens. Lactic acid bacteria are derived from the intestinal microbiota of healthy humans or dairy products. These bacteria interact with the diet and the host, contributing to protection against intestinal pathogens through colonization resistance and providing nutritional and colonic health benefits via their metabolic activities. In this study we isolated strains of Lactobacilli from Iranian traditional yogurts and identified by biochemical tests. We tested antibacterial activity of strains against Escherchia coli and salmonella typhi by spot test method. Then we assayed zone of pathogenic bacteria. Also, we determined death kinetic of pathogenic bacteria. Most of Lactobacilli strains had potential activity against the enteropathogenic bacteria of E. coli and Salmonella. This antagonistic effect against E. coli was more than Salmonella. Lactobacillus Casei showed the most preventive effect. Activity of probiotics in prevention and treatment of infections by E. coli and salmonella are effective.
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