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Articles by Mohammad Reza Fakoorziba
Total Records ( 2 ) for Mohammad Reza Fakoorziba
  Mohammad Reza Fakoorziba , Mohammad Hossein Eghbal and Fariba Eghbal
  The antidepressant drugs are long-term use administered to many patients and it can cause lot of complications and side effects. The extensive knowledge of the genetics, fitness parameters and morphology of Drosophila melanogaster has made it of the best usefulness in toxicity and genotoxicity researches. The pure strain of Drosophila melanogaster was applied for experiments. The culture was maintained under the laboratory condition. Wheat cream agar medium as standard food medium was used for maintenance of Drosophila flies. LC50 of paroxetine was estimated by the larval feeding method and sub lethal concentrations of paroxetine were selected. Viability, rate of development and sex ratio were three parameters employed to study the toxicity. The frequency of dominant lethals was scored to evaluate the genotoxic effect of this drug on male germ cell. The results have revealed that all three concentrations employed could reduce viability and significantly delay development (p<0.01). Sex ratio deviation was significant in the highest concentration (5 g L-1) whereas result of dominant lethal test showed that paroxetine was able to induce significant lethality in concentrations 0.4 and 0.5 g L-1 (p<0.05).
  Mohammad Reza Fakoorziba , Rahele Veys-Behbahani , Navid Dinparast Djadid , Kourosh Azizi and Mona Sharififard
  Despite many prevention and control programs, the disease of malaria still remains a major health and economic problem in developing countries due to the unexpected resistance of malaria mosquitoes to chemical insecticides. In this study, the virulence of 10 Iranian isolates of the entomopathogenous fungi Beauveria bassiana and Metarhizium anisoplaie were evaluated against Anopheles stephensi larvae. Different strains were screened by adding aqueous suspension of 108 conidia mL-1 to 100 mL water containing 25 early instars larvae. The results showed that Bb 429C and Bb 796C were the most virulent isolates of B. bassiana causing 100% larval mortality with lethal times of 2.29 and 2.53 days for LT50 and 4.34 and 4.34 days for LT90, respectively. Among M. anisopliae isolates, Ma 1018C was the most efficient isolate. Larval mortality rates caused by Ma 1018C at concentrations of 5x107, 108 and 5x108 conidia mL-1 were not significantly different as respectively they killed 99, 97 and 99% of larva at the fourth day. The lowest lethal times were related to the concentration of 5x107conidia mL-1 and were 0.63 and 1.93 days for LT50 and LT90, respectively. Entomopathogenic fungi could be promising prospects and safe alternatives in integrated mosquitoes control programs.
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