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Articles by Mohammad Naderi
Total Records ( 4 ) for Mohammad Naderi
  Batool Sharifi-Mood , Malihe Metanat , Roya Alavi-Naini , Hamid-Reza Kouhpayeh , Masoud Salehi , Mohammad Naderi , S. Mohammad Hashemi -Shahri and Taghi Naser-Poor
  The aim of this study was to determine the relapse rate and failure rate in the regimen of less than 6-months and this regimen was compared with the 6 month regimen. This study was an experimental clinical trial on one hundred of patients with pulmonary tuberculosis at Zahedan (a city in Southeast of Iran) in a time period of 5 years from August 1996. The study patients were adults with newly diagnosed, sputum smear positive pulmonary tuberculosis, who had no cavitation and no abnormality in more than one lobe on plain chest X-ray. Eligible patients were randomly allocated to one of the following regimens: (A) Isoniazid, Rifampicin, Pyrazinamide and Ethambutol daily for 2 months, followed by Isoniazid and Rifampicin daily for 2 months: (B) Isoniazid, Rifampicin, Pyrazinamide and Ethambutol daily for 2 months, followed by Isoniazide and Rifampicin daily for 4 months. The patients were assessed clinically and bacteriologically every month during treatment and every two months after treatment. Follow up was continued for 5 years. The results up to 5 years after treatment are presented here. Thirty three cases were treated with the 4- month regimen and 67 cases treated with the 6 month regimen. Then the relapse and failure rate was compared together for the two regimens. Over a follow-up period of 5 years, among the patients who were entered into the 4 month regimen (A), the relapse rate was 9.09% (3 cases) and the failure rate was zero. The relapse and failure rates in the 6- month regimen (B) were 8.95% (6 cases) and 4.48% (3 cases), respectively. This results showed that, there was no significant difference between two regimens in the relapse rate and the failure rate (p>0.05). Regimen of 4 months duration can achieve a high cure rate and low 5 years relapse rate in newly diagnosed patients with smear positive pulmonary tuberculosis where, there is not any report of drug resistance. Larger studies are needed to confirm these results.
  Taghi Naserpour Farivar , Mohammad Naderi , Amir Hosein Mohagheghi Fard , Hamid Oskoui Oweisi and Batoul Sharifi Moud
  In the present research, we decided to study the drug resistance rate of isolated strains to the first line of anti mycobacterium drugs: isoniazid, rifampine, ethambutol and streptomycin. All tuberculosis patient who referred to Bou-Ali hospital (the only center for training and treatment of Infectious disease in Sistan and Baluchestan province) during March 2001-July 2003 whose sputum sample smear byZNCF staining were found positive, were included in our study. After primary culture and subsequent passages, the strains of Mycobacterium tuberculosis were identified and isolated according to the growth rate, pigmentation and biochemical tests. Subsequently, drug sensitivity test of isolated was carried out by proportional standard method. In this study on 84 isolated strains of Mycobacterium tuberculosis from patients who referred to Zahedan Bou Ali hospital during March 2001-July 2003 demonstrated drug resistance to Rrifampin, Isoniazid, Streptomycin and Ethambutol was 55.9, 39.2, 33.3 and 27.3%, respectively. Present findings indicated that the prevalence of drug resistance against first line of anti TB drugs will gradually became a serious problem and targeted programs for reduction of these resistance rates is essential.
  Taghi Naserpour Farivar , Amir Hossein Mohagheghi Fard , Shahram Shahraki Zahedani , Mohammad Naderi and Batul Sharifi Moud
  This study was conducted to evaluate the anti Mycobacterium tuberculosis effects of Ocimum sanctum directly and in macrophage culture which were infected with Mycobacterium tuberculosis before treatment with different concentrations of this plant. Suspensions of bacteria were prepared in 7H9 broth and after Macrophage culture, cell suspensions of the M.tuberculosis were added to the attached macrophages. Adherent monolayers was disrupted and bacterial suspensions were serially diluted and plated onto Middle brook 7H10 agar plates. Colonies were counted under a dissecting microscope and reported as CFU. For each culture dilution, six replicate samples were plated and the mean number of colonies was calculated and then Intracellular and extra cellular killing of Ocimum sanctum extracts were measured by colony counting. Present findings showed that in a defined laboratory and macrophage culture, Ocimum sanctum has a potent anti-Mycobacterium tuberculosis effects both directly and in infected macrophage culture. In this study we confirmed anti-tuberculosis effects of different concentration of O. sanctum extracts in vitro and in Macrophage culture but key components of anti tuberculosis action of these extracts and their mechanisms of actions must be discovered in future researches.
  Batool Sharifi-Mood , Roya Alavi-Naini , Mohammad Naderi , Iman Ghasem-Zadeh and Mohammad Aminian
  A great deal of attention has focused recently on co-infection with tuberculosis (TB) and human immunodeficiency virus HIV. The objective of this study was to determine the prevalence of tuberculosis among hospitalized HIV/AIDS patients. A cross-sectional study was conducted over a period of five years from April 2000 to May 2005. The study evaluated all hospitalized HIV/AIDS patients who were admitted to a University Hospital in Zahedan. After recording the demographic data and laboratory results, final diagnosis was recorded as the cause of admission. Then all data was analyzed. Twenty-eight cases (59.5%) were treated for tuberculosis. Nineteen cases had pulmonary tuberculosis. Out of patients with pulmonary tuberculosis, 12 cases (25.5%) had smear positive pulmonary TB. Nine cases had extrapulmonary tuberculosis. Nine patients were prisoners and Injection Drug Users (IDUs) and smear positive pulmonary TB was seen in four of them. Although, the incidence rate of extrapulmonary tuberculosis and smear negative pulmonary TB in HIV/AIDS patients is more than HIV negative patients, but the present study showed that in endemic area for tuberculosis the prevalence of pulmonary TB, especially smear positive pulmonary TB is still high.
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