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Articles by Mohammad Abdollahi
Total Records ( 11 ) for Mohammad Abdollahi
  Ali Rezaie , Bardia Taghavi Bayat and Mohammad Abdollahi
  Fistulas, occurring in about 20 to 40% of Crohn’s disease patients, are usually resistant to conventional therapy of CD. Biologic therapies, which have revolutionary beneficial effects on diseases with an immunologic background, are a new horizon in treating fistulizing CD. The aim of this study was to evaluate the efficacy of biologic agents used to treat fistulizing CD after a brief overview on epidemiology and pathophysiology of fistulizing CD and definition of biologic therapy. Also it focuses on the trials and adverse effects of the biologic agents proved to be effective (Infliximab and CDP571).
  Molouk Hadjibabaie , Noushin Rastkari , Ali Rezaie and Mohammad Abdollahi
  Every drug can produce untoward consequences, even when used according to standard or recommended methods of administration. Adverse drug reactions can involve every organ and system of the body and are frequently mistaken for signs of underlying disease. Similarly, gastrointestinal tract can be affected by many drugs or chemicals. Regarding different parts of this system, these reactions can be categorized to colon, esophagus, esophagus-stomach, large intestine, liver, oral cavity, pancreas, peritoneum, rectum, small intestine, stomach, and stomach-duodenum. In this study, the drugs that may cause adverse effects in the gastrointestinal tract are reviewed. The knowledge about drug-induced gastrointestinal adverse effects helps health professionals to conduct a better practice in diagnosis of gastrointestinal tract diseases, drug administration, improvement of patients` compliance during drug therapy and may influence a more rational use of drugs.
  Afsaneh Vazin , Mojtaba Mojtahedzadeh , Ebrahim Salehifar , Noushin Rastkari , Siavash Khalaj , Ali Rezaie and Mohammad Abdollahi
  The acute respiratory distress syndrome (ARDS) is a common clinical disorder characterized by injury to the alveolar epithelial and endothelial barriers of the lung, acute inflammation and pro rich pulmonary edema leading to acute respiratory failure. Knowledge of the pathophysiology and management of ARDS has been improved immensely since its original description. But pharmacotherapies have not been hopeful in treatment of ARDS in clinical trials. Mortality from ARDS has decreased in certain centers over the last 10 years due to advances in supporting critically ill patients. This trend may open the window of opportunity for pharmacological manipulation of ARDS. This study reviews conventional and new treatment challenges like use of nitric oxide nebulizer, prostacycline, surfactants, anti-inflammatory agents, antioxidants, phosphodiesterase inhibitors, immunonutrients, prostaglandin E1, anti-interleukins and inhibitors of thromboxanes and leucotriens
  Ramesh Aghababaeian , Mahmoud Ghazi-Khansari , Khosrou Abdi , Fakhreldin Taghadosinejad and Mohammad Abdollahi
  This study was designed to explore the protective effects of sildenafil and dipyridamole from toxicity of lead in an established model of rat liver perfusion. The rats were anesthetized with ketamine and chlorpromazine. The portal vein and the inferior vena cava were cannulated and the liver was perfused in situ through the portal vein with Krebs-Henseleit buffer. After 25 min of equilibration, lead (0.5 mM) and drugs (sildenafil 50 μM, dipyridamole 50 μM) were perfused for 45 min and samples of perfused fluid were collected for assessment of thiobarbituric reactive substances as index of lipid peroxidation. Lead treatment induced a marked lipid peroxidation. Cotreatment with sildenafil and dipyridamole significantly reduced lead-induced lipid peroxidation but did not reach control values. It is concluded that lead toxicity is mediated through lipid peroxidation in rat liver which is preventable with sildenafil and dipyridamole. This action of sildenafil and dipyridamole backs to their potential to increase intracellular cGMP which seems playing as an antioxidant.
  Hournaz Karimpour , , Sarvenaz Karimpour , Mohammad Jafar Zamani , Shekoufeh Nikfar , Ali Rezaie , Naghmeh Hajarolasvadi , Shahin Shadnia and Mohammad Abdollahi
  Benzodiazepines (BZDs) are the most commonly prescribed hypnotic-anexiolytic-sedative drugs in the world. Their effectiveness and safe usage have made them extremely popular among patients. To date more than 30 different brands of BZDs have been introduced to drug market, which vary enormously in side effects, potency and indications. Thus, due to global consumption and diversity of BZDs, lack of a information indicating the BZDs` side effects sorted by induced signs and symptoms, this study would ease the consultation and follow-up of the patients who have undergone BZD treatment. The review first gives a brief introduction about side effects encountered by BZDs and then classifies the signs and symptoms based on the organ involved and mentions which BZDs are responsible for them. The organs and functions which are influenced are classified under: cardiovascular system, CNS, cognitive function, mood changes, endocrine/metabolic, gastrointestinal tract, blood and bone marrow, liver, eyes, respiratory system, skin, genitourinary tract, musculoskeletal system, ears and miscellaneous. Each of these items is also sub-grouped into several categories.
  Naghmeh Hajarolasvadi , Mohammad J. Zamani, , Parisa Sarkhail , Reza Khorasani , Masoomeh Mohajer , Gholamreza Amin , Abbas Shafiee , Mohammad Sharifzadeh and Mohammad Abdollahi
  The objective of the present study was to evaluate the anti-inflammatory and analgesic activities of the crude and fractioned extracts (ether, ethyl acetate, n-butanol and water) of Phlomis anisodonta (Lamiaceae) in the models of carrageenan-induced paw edema and acetic acid-induced writhing in mice. Dried powdered material from the aerial parts of Phlomis anisodonta was extracted with methanol (80%) twice. The methanol extract was separated into four fractions: after drying the methanol extract, the solid residue was dissolved in water and the water-soluble portion was successively partitioned to produce the above-mentioned fractions. The total extract, ether fraction and ethyl acetate fractions significantly reduced the number of writhings compared to the control group. Water and n-butanol fractions showed no analgesic activity. Neither the total extract nor four fractions were more effective than indomethacin in acetic acid-induced test. In carrageenan-induced inflammation test, only water and ethyl acetate fractions showed antiinflammatory activity compared to the control group. The total extract, n-butanol and ether fractions showed no antiinflammatory activity. Neither the total extract nor four fractions were more effective than indomethacin. Different types of glycosides found in the genus Phlomis could be responsible for observed effects. Variations in antiinflammatory and analgesic effects of different fractions of this plant might be attributed to the fact that different fractions of P. anisodonta contain active compounds in variable ratios and activities. A comprehensive analysis for determination and quantification of these compounds is required).
  Sheyda Hoseini , Hadi Esmaily , Azadeh Mohammadirad and Mohammad Abdollahi
  In the present study, the effects of short-term administration of sildenafil a selective PDE5 inhibitor on serum glucose and hepatic glycogenolysis and gluconeogenesis were examined in rats in vivo. Sildenafil was administered intraperitoneally at doses of 0.5, 1.0 and 5.0 mg kg-1. Two hours post treatment, liver was perfused, removed and homogenized. The activities of the key enzymes of glycogen phosphorylase (GP) and phosphoenolpyruvate carboxykinase (PEPCK) were analyzed in the homogenate. The high dose of sildenafil (5 mg kg-1) caused a significant reduction in serum glucose levels in comparison to control group (94.6±4.7 vs. 121.16±6.05 mg dL-1). The activity of PEPCK remained unchanged when animals were treated with various doses of sildenafil. Interestingly, sildenafil reduced hepatic GP at all doses administered (20.31±1.42, 17.18±1.2, 15.69±1.1 vs. 25.8±1.8 U g-1 liver protein for control group). It is concluded that administration of sildenafil markedly reduces liver glycogenolysis which in turn lowers blood glucose concentration at higher doses. This effect of sildenafil seems to be in relation with its NO mimicking potential and antioxidant properties. The underlying mechanisms involved seem complicated since parallel increase in the activities of GP and PEPCK was not observed.
  Atousa Aliahmadi , Nasim Rahmani and Mohammad Abdollahi
  Biotechnology has offered important and efficient means for improving human life and health. However in spite of incredible development of biotechnological procedures, there are problems in point of economical view, especially in the case of products which are needed in huge amounts and relate to human health, such as vaccines. Application of biotechnology in such way that eliminates or reduces time-consuming and expensive processes, regarding production and subsequent quality control steps, can help better vaccination programs for large population, especially in the developing countries. The aim of this study was to summarize all data about human plant-based vaccine development including candidate antigens, transgenic plants and corresponding immunological responses in animal models or human using complete literature bibliography. The conclusion is that viral vaccines have been studied more than bacterial ones. Crude extracts of transformed plant materials as well as purified recombinant antigens expressed in plants have been found to induce immunological response in some investigations. Most of animal studies have been done with great success. Although few studies have been performed in humans but most of them have lead to hopeful results. Presently none of the commercially available products are produced in plants while most of biotechnology products which are comprised of proteins and possibly DNA-based vaccines are good potential candidates for plant-based production. Continuing investigations on plant-based vaccines is very crucial.
  Akram Ranjbar , Sara Ghaseminejhad , Hassan Takalu , Akram Baiaty , Fatemeh Rahimi and Mohammad Abdollahi
  Regarding role of oxidative stress in operating room personnel and the anti oxidative stress potential of Cinnamon zeylanicum (cinnamon) in healthy subjects, the present study aimed to examine anti oxidative stress potential of cinnamon in operating room personnel. A group of 18 operating room personnel was invited to drink cinnamon (100 mg/300 mL tea) once daily for 10 days. Blood samples were obtained before and after entering the study and plasma was measured for oxidative stress biomarkers including Lipid Peroxidation Level (LPO), Total Antioxidant Power (TAP) and Total Thiol Molecules (TTM). Treatment of subjects with cinnamon induced a significant reduction in plasma LPO (5.03±2.01 vs. 3.25±1.32 nmol mL-1, p = 0.016). No statistically significant alteration was found for plasma TAP (1.24±0.12 vs. 1.28±0.12, p>0.05) and TTM (0.78±0.05 vs. 0.82±0.03, p>0.05) after 10 days treatment by cinnamon. In conclusion, reduction of cellular LPO by cinnamon as a dietary supplement can be a rational protocol to control source of hazards in operating room personnel.
  Mona Babaie , Narguess Yasa , Azadeh Mohammadirad , Reza Khorasani and Mohammad Abdollahi
  The present study was undertaken to explore the antioxidants effects of Zataria multiflora Boiss in rats. Antioxidant activity was measured by inhibition of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, Total Antioxidant Power (TAP) and Thiobarbituric Acid Reactive Substances (TBARS) in serum of treated rats. Rats received methanolic extract of Z. multiflora by intragastric intubation at doses of 50, 100 and 200 mg kg-1 daily for 14 consecutive days. The acute toxicity test (LD50) demonstrated that Z. multiflora is not lethal up to a dose of 2000 mg kg-1 after oral administration. Treatment of rats with Z. multiflora extract showed significant antioxidant activity in the DPPH test as compared to the control. Z. multiflora at doses of 50 and 100 mg kg-1 significantly increased TAP and decreased TBARS as compared to the control. Administration of Z. multiflora at a dose of 200 mg kg-1 per day did not significantly alter serum DPPH, TAP and TBARS. Antioxidant activities of Z. multiflora at doses of 50 and 100 mg kg-1 were in all experiments comparable to that of α-tocopherol. Further studies are needed to elucidate whether Z. multiflora as herbal medicine could be useful in the management of human diseases resulting from oxidative stress.
  Mohammad Sharifzadeh , Mahsa Raoufi , Amir Abbas Zahedinejad , Nourollah Aghaebrahimi , Kurdistan Sharifzadeh and Mohammad Abdollahi
  The effects of chronic lead acetate treatment on alterations of Auditory Brainstem Response (ABR) induced by gentamicin and amikacin were tested in guinea pigs. This study was designed to investigate the hypothesis that aminoglycoside antibiotics and lead via their effects on phosphoinositide pathway and calcium channels may influence ototoxicity mechanisms as tested on the auditory brainstem response. Intramuscular injection of different doses of gentamicin (5, 10 mg/kg/day) and amikacin (150, 300 mg/kg/day) for three weeks induced hearing loss. Administration of lead acetate (0.05%, 35 days) in drinking water changed ABR (absolute wave latency). The gentamicin-induced alteration of ABR were attenuated by chronic lead acetate pretreatment in guinea pig. Obtained data suggest the interactions between chronic lead acetate and aminoglycoside antibiotics in alterations of auditory functions which could be accounted for, at least partially, by perturbations of the phosphoinositide and calcium cascades within the inner ear.
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