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Articles by Mohammad A. Rashid
Total Records ( 2 ) for Mohammad A. Rashid
  M. Sekendar Ali , M. Abdullah Al Mamun , Mohammed Abu Sayeed , Mohammad S. Rahman and Mohammad A. Rashid
  Bangladesh is a good repository of medicinal plants. Traditional healers utilize them for treating many pathological states. Unfortunately, very few of them have been scientifically evaluated to know about the deep inside. The current study here is designed to evaluate the in vivo sedative activity of the leaves of Glochidion multiloculare (Rottler ex Willd) Voigt. With this purpose, the plant leaves were collected and powdered for extraction with methanol. Initially, the plant extract was subjected to brine shrimp lethality bioassay to monitor the presence of bioactive molecules. Later on, different neuropharmacological studies including hole cross, open field, thiopental-sodium induced sleeping time and Elevated-Plus Maze (EPM) tests were conducted to investigate sedative action. In the brine shrimp lethality bioassay, the LC50 value of the extract was found 37.19 μg mL-1, whereas the standard vincristine sulphate showed the LC50 10.50 μg mL-1. The moderate toxicity of the extract on brine shrimp indicated the existence of bioactive secondary metabolites in this extract. Besides, the extract decreased the locomotor activity of mice in hole cross, open field and EPM test indicating the CNS depression capability of the plant. Moreover, the extract was very much effective for prolonging the sleeping time (103 min) with quick onset of action (22 min) in comparison to the control group. The efficacy of the plant extract was found closer to the common sedative drug diazepam. Further investigations are required to explore the underlying mechanism of the sedative action and isolate bioactive principles.
  Akhtaruzzaman Chowdhury , Md. Ashraful Alam , Ridwan Bin Rashid , Muhammad Abdullah Al-Mansur , Mohammad S. Rahman and Mohammad A. Rashid
  Corypha taliera Roxb. is a critically endangered palm species. The tree grown in the campus of the University of Dhaka, Bangladesh used to be considered as the only living species in the world. This palm tree raised some interests due to several bioactivities observed earlier and later systematic scientific studies have been undertaken to explore for its secondary metabolites. In the present study, a thorough phytochemical investigation was conducted to explore its chemical features. Initially, the unripe fruits of this palm was extracted with methanol. Later on, it was fractioned by the modified Kupchan partitioning method in to n-hexane, carbontetrachloride, chloroform and aqueous soluble fractions. The n-hexane soluble fraction was subjected to Column Chromatography (CC) over Sephadex LH-20 and the column was eluted with n-hexane-dichloromethane-methanol (2:5:1) mixtures. From the collected fractions stigmasterol (1), β-sitosterol (2), β-amyrin (3), lupeol (4) and betulinic acid (5) were isolated by Preparative Thin Layer Chromatography (PTLC). The structures of these purified compounds were established by extensive spectroscopic analysis and by comparison of their spectral data with published values as well as co-TLC with authentic samples. This is the first report of isolation of steroids and terpenoids from this plant.
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