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Articles by Mohamed A. Shalaby
Total Records ( 2 ) for Mohamed A. Shalaby
  Omar M. Yousef , Mohamed El Raaey , Tamer H. El Shaarawy , Ahmed A. El Sanousi and Mohamed A. Shalaby
  In this study, we investigated the in vitro antiviral potential of Quercus ilex (wood) extract against Bovine Viral Diarrhea Virus (BVDV), a pestivirus model of Hepatitis C Virus (HCV), in comparison to extracts of green tea (Camellia sinensis) and pomegranate (Punica granatum) which are previously reported to possess antiviral properties. The Crude Aqueous Methanol Extracts (CAMEs) of Q. ilex (wood), P. granatum (rind) and C. sinensis (leaves), besides crude ethanolic extract (CEE) of P. granatum (arils) were firstly evaluated for cytotoxicity on MDBK cell line. Afterward, evaluated for their in vitro antiviral activities against (BVDV) by means of (MTT/ XTT) based colorimetric assays. The Q. ilex (wood) CAME exhibited an evident anti-BVDV activity which was found to be more pronounced than the other tested plant extracts on MDBK cells with inhibitory percentage (IP)>97% at virus dose of 10 and 100 TCID50. Q. ilex (wood) extract has shown antiviral activity, thus suggesting this plant extract as a candidate for further activity-monitored fractionation to recognize its active constituents.
  Omar M. Yousef , Mohamed El-Raey , Ahmed A. El Sanousi and Mohamed A. Shalaby
  In this study, the antiviral effect of holm oak wood extract was investigated against (H9N2) virus, which belongs to the group of influenza (A) viruses that cause serious diseases to human and animal, this in vitro study was carried out in comparison to Amantadine HCl (AMN) in addition to extracts of green tea leaves and pomegranate fruit rinds and arils, as these substances have shown previously a considerable antiviral properties against influenza (A) viruses. Initially, cytotoxicity examination was conducted for the crude aqueous methanol extracts (CAMEs) of Quercus ilex L. (wood), Camellia sinensis (leaves) and Punica granatum (rind), besides crude ethanolic extract (CEE) of P. granatum (arils) on MDCK cell line. This was followed by evaluation for their in vitro antiviral activities against AMN resistant (H9N2) virus infection on the same cell line using MTT based colorimetric assays. Holm oak wood extract Showed visible antiviral effect against (H9N2) influenza virus on MDCK cells, where the virus inhibition percentage exceeded 97% at the viral dose of (50 TCID50) and was equivalent for large extent to the antiviral effect shown by green tea extract against the same virus, despite the comparatively more toxic effect of green tea extract on MDCK cells. On the other hand, the pomegranate extracts unexpectedly exhibited much less Influenza virus inhibitory effects than the former extract. Based on the results revealed in this study, the virus inhibitory effects shown by the holm oak wood extract, suggest this plant as promising one that need more research to find out its active components that may be useful in the development of new effective antiviral agents.
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