Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by Mohamed A. Al-Douis
Total Records ( 1 ) for Mohamed A. Al-Douis
  Yahya S. Al-Awthan , Mohamed A. Al-Douis , Gamal H. El-Sokkary and Esam M. Aqlan
  Dimethoate (DM), an organophosphate insecticide, has been used worldwide in agriculture and domestic for several years which has led to a variety of negative effects in non target species including humans. Therefore, the present study investigated the ameliorative properties of vitamin C (vitC) and E (vitE) on DM toxicity of guinea pigs. The animal groups were orally administered with either vehicle, vitC (200 mg kg-1 body weight) and vitE (200 mg kg-1 body weight), 1/50 LD50 of DM (7 mg kg-1 b.w.) and 1/50 LD50 of DM + vitC and vitE daily for 28 days. Administration of DM resulted in a significant increase in the levels of various serum marker enzymes (AST ALT and ALP). Similarly, significant increase in Lipid Peroxidation (LPO) level while induced significant decreases in the activities of liver Catalase (CAT) and Glutathione-S-Transferase (GST). In contrast, co-administration of vitC and vitE to DM-treated animals restored most of these biochemical parameters to nearly normal levels. Also, DM induced histopathological alterations such as cytoplasmic vacuolization and degeneration in nuclei, congestion, an enlargement of the blood vessels and lymphocytes infiltration in the liver. These changes were ameliorated by vitamins co-administration. The results showed that co-treatment of vitE and vitC protected guinea pigs from DM-induced biochemical and histopathological changes.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility