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Articles by Moamen S. Refat
Total Records ( 4 ) for Moamen S. Refat
  Ahmed M. Naglah , Mohamed A. Al- Omar , Samy M. El- Megharbel and Moamen S. Refat
  Metal complexes have been applied as medicinal agents in the treatment of different human infections and diseases. So, the aim of this study is focused on studying the spectroscopic, thermal and evaluating antimicrobial investigations of ibuprofen analgesic drug complexes formulas with Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) metal ions. Complexes of Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) with ibuprofen ligand as to evaluate the biological activity were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-VIS, IR, 1H-NMR spectroscopy and thermal analysis. The IR spectral data suggested that the ibuprofen ligand behaves as a monobasic bidentate ligand towards the central metal ion with deprotonated of carboxylic group. From the microanalytical data, the stoichiometry of the complexes 1:1, 1:2 and 1:3 (metal: ligand) was found. The metal complexes were screened for antibacterial activity against Gram -ve organisms as Escherichia coli and Pseudomonas aeruginosa, Gram +ve organisms as Bacillus subtilis and Bacillus cereus and antifungal organisms such as Aspergillus niger, Aspergillus flavus and Aspergillus oryzae. The resulted Ibu compounds has proved the thermal stability feature. The antimicrobial activities of the metal complexes of Ibu recorded a significant effect against some bacteria and fungi.
  Ahmed M. Naglah , Mohamed A. Al- Omar , Abdel Majid A. Adam and Moamen S. Refat
  Saccharin (sacH) is a sugar substitute sweetening agent used extensively in dietary products. It is about 300 times sweeter than sucrose. This study highlighted the structural chemistry of Charge Transfer (CT) complexes formed from the interactions of two acido acceptors (CLA and PA) with sacH. The IR and 1H NMR revealed evidence of significant intermolecular interactions between N-H group in the sacH and O-H group in the acido acceptors based on their characteristic shifts. The TG and DTA experiments were carried out to investigate the thermal properties of the obtained complexes. Their morphological features were also investigated using Optical Light Microscope (OLM). The OLM micrograph patterns indicate the formation of high quality colored crystals. This study provided the essential basics for understanding the complexation chemistry of saccharin.
  Moamen S. Refat , Sabry A. EL-Korashy , Deo Nandan Kumar and Ahmed S. Ahmed
  The complexes of alloxan with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) Cd(II), Hg(II), Ti(IV) and Zr(II) have been isolated and characterized on the basis of elemental analysis, molar conductivity, spectral studies (mid infrared, 1H-NMR and UV/vis spectra), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The thermal decomposition of the metal complexes was studied by thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The kinetic thermodynamic parameters, E*, ΔH*, ΔS* and ΔG*, were calculated using Coats and Redfern and Horowitz and Metzger equations. The ligand and its complexes have been studied for possible biological activity including antibacterial and antifungal activity.
  Moamen S. Refat , Ibrahim M. El-Deen , Zeinab M. Anwer and Samir El-Ghol
  Synthesis and spectroscopic characterization of Schiff-base complexes of Cu(II), Ni(II), and Mn(II) resulting from condensation of salicylaldehyde derivatives with thiosemicarbazide [PHBT = 1-(5-(2-phenyldiazenyl)-2-hydroxybenzylidene)thiosemicarbazide, CHBT = 1-(5-(2-(2-chlorophenyl)diazenyl)-2-hydroxybenzylidene)thiosemicarbazide, and MHBT = 1-(5-(2-p-tolyldiazenyl)-2-hydroxybenzylidene)thiosemicarbazide] are discussed. The solid complexes were confirmed by elemental analysis (CHN), molar conductance, and mass spectra. Important infrared (IR) spectral bands corresponding to the active groups in the three ligands, 1H-NMR and UV-Vis spectra and thermogravimetric analysis were performed. The dehydration and decomposition of [Cu(PHBT)(H 2O)], [Ni(PHBT)(H 2O)] · 2H2O, [Mn(PHBT)(H 2O)] · H 2O, [Cu(CHBT)(H 2O)], [Ni(CHBT)(H 2O)] · H 2O, [Mn(CHBT)(H 2O)] · H 2O, [Cu(MHBT)(H2O)], [Ni(MHBT)(H 2O)] · 2H 2O, and [Mn(MHBT)(H 2O)] · 2H 2O complexes were studied. The ligands are tridentate forming chelates with 1 : 1 (metal : ligand) stoichiometry. The molar conductance measurements of the complexes in DMSO indicate non-electrolytes. The biological activities of the metal complexes have been studied against different gram positive and gram negative bacteria.
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