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Articles by Mingzhou Li
Total Records ( 3 ) for Mingzhou Li
  Mingwang Zhang , Mingzhou Li , Long Jin , Yan Li and Xuewei Li
  Tibetan pig is an endangered plateau type pig breed which distributed mainly in Qinghai-Tibetan Plateau. In present study, researchers analyzed 218 prior published partial mitochondrial D-loop sequences (415 bp) by using phylogenetic, network, mismatch distribution and Analysis of Molecular Variance (AMOVA) analysis to clarify the population differentiation and explore the relationships among populations from different geographical locations of Tibetan pigs. The results revealed a total of 43 haplotypes in 218 samples from seven Tibetan pig populations in which only one common Haplotype (H1) was shared by the seven populations. Haplotype diversity was high (0.889) whereas nucleotide diversity among all individuals was low (0.00534). It is notable that Hezuo Tibetan pigs have 19 unique haplotypes in total 24 haplotypes of 53 individuals with the highest nucleotide diversity (0.00765). Bayesian tree and median joining network procedures carried out on the data showed that seven Tibetan pig haplotypes were essentially indistinguishable except some unique haplotypes from Hezuo. The AMOVA analysis indicated that the genetic variation mainly occurred within populations (85.41%) but variance among populations was only 14.59%. The unimodal mismatch distribution of haplotypes, together with significant negative values of Fu’s FS and negative values of Tajima’s D suggest that a recent population expansion of Tibetan pig has been occurred in Diqing, Hezuo and total population.
  Yihui Liu , Jideng Ma , Li Chen , Pengbo Lou , Jun Zhou , Mingzhou Li and Xuewei Li
  High-throughput sequencing of two small RNA libraries derived from immature (20 days old) and mature (210 day old) porcine testis samples yielded over 20 million high-quality reads. Researchers detected 461 mature microRNAs (miRNAs) encoded by 277 precursor (pre)-miRNAs of which 428 were unique. In total, 303 unique miRNAs of (428, 70.79%) were differentially expressed between immature and mature porcine testes. Compared with immature testis, 95 unique miRNAs were up-regulated and 208 unique miRNAs were down-regulated in mature testis. Strikingly, researchers found that most miRNAs and differentially expressed miRNAs were preferentially located on the X chromosome which implied their crucial roles in the sex-determination system. Furthermore, GO and KEGG analyses of the target genes that were predicted from the highly abundant differentially expressed miRNAs between mature and immature porcine testes illustrate the likely roles for these miRNAs in spermatogenesis. The study indicates that miRNAs are extensively involved in spermatogenesis and that unraveling miRNA functions in the testis will further the understanding of regulatory mechanisms of mammalian spermatogenesis and male infertility treatment.
  Jian Xiao , Jideng Ma , Long Jin , Xuewei Li , Mingzhou Li and An-An Jiang
  The liver is a vital organ that plays a major role in metabolism and other functions in the body. In this study, researchers used microarray analyses to investigate the gene expression profile during the development of the liver in pigs (Suss crofa). Researchers identified various differentially expressed genes in the liver between the prenatal and postnatal stages. The upregulated genes in the prenatal liver were related to the cell cycle and developmental process. The genes that were upregulated in the postnatal liver were active in the immunological process. The study presented gene expression profiles of the porcine liver during the pre and post-natal stages which contribute to the understanding porcine liver development.
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