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Articles by Min-Tze Liong
Total Records ( 3 ) for Min-Tze Liong
  Hassan Pyar , Min-Tze Liong and K.K Peh
  The search for new culture media that will encourage the growth and production of active antimicrobial metabolites by probiotics has become of utmost importance in the light of increasing bacterial resistance and the high costs of commercial media to cultivate the probiotics. Hence, the study was aimed at characterizing and determining the activity of metabolites obtained from Lactobacillus acidophilus strains cultivated in two novel media against pathogenic bacteria. Eight strains of L. acidophilus were cultivated in Morinda citrifolia juice and Glycine max extract. Bacterial metabolites were harvested and evaluated for antibacterial activity against two human pathogens, Staphylococcus aureus and Escherichia coli. All tested metabolites of L. acidophilus strains showed significant bactericidal activity, as indicated by zone of inhibition in the culture plates compared with control. There was a statistically significant difference in the activity of the metabolites against S. aureus and E. coli. Metabolites of L. acidophilus FTDC-4462 strain exhibited the highest zone of inhibition against S. aureus and E. coli in both growth media. Metabolites of L. acidophilus strains were more effective against S. aureus than E. coli. There were no significant differences in the growth media on antimicrobial effect of the metabolites of L. acidophilus against E. coli and S. aureus. Metabolites of L. acidophilus significantly inhibited the growth of both pathogenic bacteria used and can be used as potential antibiotic or probiotic agents. M. citrifolia juice and G. max extract could be used as novel and cheap culture media for L. acidophilus to produce antibacterial metabolites.
  Hassan Pyar , Min-Tze Liong and K.K. Peh
  Probiotics are defined as “microbial food supplements” with favorable effects on the consumers. The selection of probiotic microorganisms depends on a number of aspects including safety, functional and technological characteristics. Increased incidence of microbial resistance to antibiotics has triggered renewed efforts to develop probiotics in the treatment of gastric aliments. This review outlines the uses of probiotics and their novel applications and developments for healthcare. The biomedical applications of probiotics in the prophylaxis and treatment of different disease conditions such as diarrhea, constipation, hypercholesterolaemia, vaginitis, necrotizing enterocolitis, sepsis, colon cancer, bladder cancer, breast cancer and liver cancer are discussed. Furthermore, stimulation immune system, weight gain improvement in premature infants, reduction of incidence of respiratory tract infections and prevention of intestinal infections are also highlighted and current challenges are described.
  Hassan Pyar , K.K. Peh and Min-Tze Liong
  In the present study, the effects of combined metabolites produced by lactic acid bacteria were tested on food pathogenic and contaminant microorganisms. Totally, eight strains of Lactobacillus acidophilus (FTDC 2804, FTDC 0785, FTDC 8592, FTDC 1295, FTDC 4793, FTDC 4462, FTDC 0582 and FTDC 2916) were used which cultivated in four types of agro waste substrates including pineapple waste, soy whey, cabbage and molasses. The inhibitory effects of L. acidophilus metabolites (lactic acid, hydrogen peroxide, acetaldehyde, diacetyl and bacteriocin) were determined by agar well diffusion method on two pathogenic bacteria; Staphylococcus aureus and Escherichia coli. Metabolites of different L. acidophilus strains cultured in different agro waste substrates showed diverse inhibitory effects. Among all, the highest inhibition zone was obtained with the strains cultivated in pineapple waste, such as, L. acidophilus FTDC 4462 strain (10.57±0.10 mm for S. aureus and 11.13±0.45 mm for E. coli). It can be concluded that L. acidophilus species has the ability to grow in agro waste materials and produce beneficial metabolites with antibacterial activities.
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