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Articles by Miao Pan
Total Records ( 2 ) for Miao Pan
  Jennifer Smith , Joanna Manoranjan , Miao Pan , Amro Bohsali , Junjie Xu , Jun Liu , Kent L. McDonald , Agnieszka Szyk , Nicole LaRonde-LeBlanc and Lian-Yong Gao
  The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum, but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium-containing vacuole (MCV) into the host cell cytosol, polymerize actin, and spread from cell to cell. In this study, we have examined nine M. marinum ESX-1 mutants and the wild type by using fluorescence and electron microscopy detecting MCV membranes and actin polymerization. We conclude that ESX-1 plays an essential role in M. marinum escape from the MCV. We also show that the ESX-1 mutants acquire the ability to polymerize actin after being artificially delivered into the macrophage cytosol by hypotonic shock treatment, indicating that ESX-1 is not directly involved in initiation of actin polymerization. We provide evidence that M. marinum induces membrane pores ∼4.5 nm in diameter, and this activity correlates with ESAT-6 secretion. Importantly, purified ESAT-6, but not the other ESX-1-secreted proteins, is able to cause dose-dependent pore formation in host cell membranes. These results suggest that ESAT-6 secreted by M. marinum ESX-1 could play a direct role in producing pores in MCV membranes, facilitating M. marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection.
  Xiaoyan Yin , Miao Pan and Wei Wei
  The beyond 3G or 4G mobile systems are envisioned to be characterized by the pouring of diverse services supported by various RANs (Radio Access Networks) belonging to different operators. In parallel with this, how to utilize efficiently the limited radio spectrum and guarantee the operator’s profits has emerged as a joint economical and technical problem. As a possible solution, in this study, a bilateral bargaining approach is proposed for Dynamic Spectrum Management (DSM) based on bargaining games under incomplete information in microeconomics. In the context of distributed reconfigurable networks controlled by different operators, bilateral bargaining DSM (BBDSM) scheme introduces Trading Agents (TA), trading mechanisms as well as reasonable bargaining strategies to facilitate DSM. Related technologies, bargaining games and proposed algorithm are also described in details. Simulation results show that with imperfect load predicting, BBDSM is effective in improving the utilization of spectrum, expanding the individual operator’s profits.
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