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Articles by Memduh KAYMAZ
Total Records ( 2 ) for Memduh KAYMAZ

Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and long-chain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma multiforme (GBM) (n = 29), high-grade astrocytoma (n = 8) and low-grade astrocytoma (n = 8)] to determine whether there is a relation between carnitine-acyl carnitines and lipid peroxidation in carcinogenesis.

Materials and Methods: The present study examined the free carnitine and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 levels of glial tumors in tandem mass spectrometry. We measured MDA levels using HPLC system.

Results: There was a significant correlation between MDA and C20:4 carnitine levels in GBM. C20:4 carnitine levels increased with increasing MDA levels (p = 0.000, r = 0.916), but no significant correlation was found in the other groups.

Conclusions: In conclusion, measurement of only carnitine-MDA relation did not reflect any significant correlation. Detailed studies, including measurement of parameters showing antioxidant status and tumor cellular metabolism, are necessary.

  Berrin GUNAYDIN , Sema ONCUL , Mehmet ERDEM , Memduh KAYMAZ , Hakan EMMEZ and Zerrin OZKOSE
  Cesarean delivery of a parturient suffering from paraplegia followed by anterior corpectomy and posterior spinal cord decompression because of spine metastasis at T1 due to breast cancer was presented. General anesthesia was uneventfully completed after rapid sequence anesthesia induction with propofol, ketamine, and succinylcholine, which was maintained by isoflurane inhalation in 50% oxygen-air mixture until delivery of the newborn. After delivery, remifentanil infusion was added to isoflurane inhalation in approximately 33%/66% oxygen:air until skin closure of the latter operation. Consequently, satisfactory recovery of paraplegia resulting from spine metastasis and delivery of a healthy baby were provided by successful and uneventful management of sequential caesarean delivery and neurosurgical intervention requiring double different positioning successively under general anesthesia.
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