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Articles by Mehran Majlesi
Total Records ( 3 ) for Mehran Majlesi
  Safieh Golkhani , Mehrdad Modaresi and Mehran Majlesi
  Balm (Melissa officinalis) is a fragrant plant from Laminacea family which has many medical properties including relaxing, anti-oxidant and anti-bacterial. This study was conducted to investigate the effect of hydro alcoholic extract of balm on activity of liver enzymes including AST, ALT and ALP and also liver tissues variation in Balb/C mice. Samples were randomly divided into five groups (three treatment groups, placebo and control group) with eight members in each group. Groups were kept under similar conditions. Hydro alcholic extract was prepared in three doses (50,100 and 200 mg kg-1) and were IP for 20 days. Normal saline was used for placebo group. After the last injection blood samples were taken and liver tissues were separated. Changes of AST, ALT and ALP enzymes was evaluated using one way variance analysis and SPSS program (p<0.05). Tissue changes of liver were studied using coloring with H&E technique. According to results, ALT and ALP enzyme was increased (p<0.05) in 200 mg kg-1 dose. Hepatocytes number and histology of liver didn’t show significant variations. On the whole, hydro alcoholic extract of balm could have conservative effects via reducing ALT and ALP enzymes and no harmful effects on liver tissue. So, it can play an important role in preventing and curing diseases in traditional and also current medicine.
  Lida Yadekari , Mehrdad Modaresi and Mehran Majlesi
  Lettuce (Lactuca sativa L.) is one of the most important vegetables in herbal medicine. This plant is belonging to Asteraceae family and has many therapeutic properties in traditional medicine. This study was conducted to investigate the effect of hydro alcoholic extract of lettuce on blood indices, sugar, insulin, cholesterol, triglyceride, HDL and LDL in Balb/C mice. Forty mice with about 25 g weight and the age range of 3-4 months were divided randomly in five groups including control, placebo and three experimental groups. All groups were kept under similar conditions. Hydro alcoholic extract of lettuce were prepared in 50, 100 and 200 mg/kg/day doses and IP injected of treatment groups for 20 days. Normal saline was used to inject to placebo group. The most important studied parameters were number of red and white blood cells, hematocrite, MCH, MCV, MCHC, sugar, insulin, cholesterol, triglyceride, HDL and LDL. At the end of study blood samples were taken and following results were obtained: Red blood cells and hematocritee were decreased significantly in 100 and 200 mg treatments whereas white blood cells were increased significantly (p<0.05) in these treatments. Blood sugar was significantly decreased in all three treatment groups and insulin was reduced only in 200 mg group significantly. Also, cholesterol of 50 mg group reduced significantly whereas other parameters no changed. On the whole, hydro alcoholic extract of lettuce can have positive effects on white blood cells, sugar, insulin and cholesterol dose-dependently.
  Safieh Golkhani , Mehrdad Modaresi and Mehran Majlesi
  Balm (Melissa officinalis) is a fragrant plant from Laminacea family which has many medical properties including relaxing, anti oxidant and anti bacterial. This study was conducted to investigate the effect of hydro alcoholic extract of balm on activity of liver enzymes including AST, ALT and ALP and also liver tissues variation in Balb/C mice. Samples were randomly divided into five groups (three treatment groups, placebo and control group) with eight members in each group. Groups were kept under similar conditions. Hydro alcholic extract was prepared in three doses (50, 100 and 200 mg kg-1) and were IP for 20 days. Normal saline was used for placebo group. After the last injection blood samples were taken and liver tissues were separated. Changes of AST, ALT and ALP enzymes was evaluated using one way variance analysis and SPSS program (p<0.05). Tissue changes of liver were studied using coloring with H&E technique. According to results, ALT and ALP enzyme was increased (p<0.05) in 200 mg kg-1 dose. Hepatocytes number and histology of liver did not show significant variations. On the whole, hydro alcoholic extract of balm could have conservative effects via reducing ALT and ALP enzymes and no harmful effects on liver tissue. So, it can play an important role in preventing and curing diseases in traditional and also current medicine.
 
 
 
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