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Articles by Mehmet Ozaslan
Total Records ( 17 ) for Mehmet Ozaslan
  Mehmet Ozaslan , Mehmet Emin Zumrutdal , Kenan Daglioglu , Ibrahim Halil Kilic , Isik Didem Karagoz , M.E. Kalender , Muhittin Tuzcu , Omer Colak and Beyhan Cengiz
  In recent years, prophylactic usage of natural products and tendency to resort to alternative medicine has increased rapidly. Henna (Lawsonia sp.) has been used not only cosmetically but also medicinally in Turkish population. Among the studies of henna’s antifungal, anti-microbial, tuberculostatic and antitumoral effects come on the science. In this study, we planned to research the effect of Lawsonia inermis that is an oxidant agent against development of cancer, by constituting peritonitis carcinomatous with Ehrlich ascites cells. The animals were divided to three groups and Lawsonia inermis extract and tap water were given to mice for 5 days. After 5 days, all of animals were decapitated by cervical dislocation and their liver tissues were sampled to measure reduced glutathione (GSH) level. Mean Survival Time (MST) and Average Survival Time (AST) were calculated; peritoneal liquid pH was measured; Ehrlich Ascites Carcinoma (EAC) cells were counted with hemocytometer. At the result, the longest life period was detected on the group which was given 10 mg/kg/day Lawsonia inermis. In group 2 and 3 which were given Lawsonia inermis following to forming Ehrlich ascites carcinoma, total number of cancer cell decreased. The scaled pH levels belonging to group 2 and 3 changed into alkaline compared to that of group1 (pH = 6.2). Glutathione levels of liver tissue were determined to decrease in group 2 and 3 in comparison with group1. In conclusion, Lawsonia inermis may lead cells to apoptosis related to deficiency in detoxification of intracellular radicals.
  Emin Zumrutdal and Mehmet Ozaslan
  Lawsonia inermis is a plant that is widely distributed across the Sahel and Central Africa. It also exists in the Middle East. It is a much-branched glabrous shrub or small tree of about 2-6 m high, which may be spiny. Lawsonia inermis plant is cultivated in Africa and Asia for both medicinal and industrial (dyeing) purposes. Just as people use it for staining hair, nails and beard, it is pointed that Lawsonia inermis is used for various fields in medicine. Hepatoprotective and immunomodulatory effect, antimicrobial, anthelminthic, antifungal, antitrypanosomal, abortifacient, antioxidant and anticancer activity of Lawsonia inermis were reported from all over the world by previous studies. The early studies about Lawsonia inermis against to Ehrlich Tumors in mice in Turkey were started by Dr. Emin Zümrütdal from Adana Numune Training and Research Hospital and his colleagues at University of Cukurova Adana, Turkey. This study aimed to review the available literature on some of the ethno-botanical uses of seeds, leaves and roots of Lawsonia inermis plant.
  Shaymaa Fadhel Abbas Albaayit and Mehmet Ozaslan
  Background and Objective: Moringa peregrina have long been used as traditional medicine to treat diseases including fever, ulcer, burns and constipation, antimicrobial and inflammatory throughout the African mainland. The objectives of current study were to evaluate the cytotoxic and urease inhibitory profile of Moringa peregrina seed ethanolic extract (MPSE). Materials and Methods: Brine shrimp lethality bioassay was used to determine the cytotoxic effect of MPSE treatment at concentrations 1000, 100 and 10 μg mL1. Urease inhibition was determined by in vitro Indophenol inhibition assays. Results: It is found that the Moringa peregrina seed ethanolic extract was not cytotoxic at 1000 μg mL1 while significantly active with urease inhibitor (81.30±0.31% at 0.2 mg mL1) with IC50 values of 41.0±0.6 μg mL1. Conclusion: These findings suggested that the Moringa peregrina seed ethanol extract (MPSE) can be utilized to treat and prevent ulcerative and Urolithiasis diseases through urease inhibition process. Seed extract of M. peregrina is a remarkable candidate for further clinical investigation studies to screen out their natural therapeutic potential in ulcerative and urolithiasis diseases.
  Mehmet Ozaslan
  Not Available
  Idress Hamad Attitalla and Mehmet Ozaslan
  In current era pets are important part of the social life. Moreover, increased use of animal assisted therapies in treatment of people with special needs gives a glimpse of their beneficial role in future. Dogs are one of the commonly adopted animals as pet and more often develops an intimate relation with their owners. Hence, chances of disease transfer from dogs to humans are high. In this review some important bacterial diseases of dogs are discussed with respect to their DNA based diagnosis. PCR was found to be effective for detection of diseases in most of the cases. To distinguish between pathogenic and nonpathogenic strains of an organism, combination of PCR with other DNA based diagnostic techniques like Restriction Fragment Length Polymorphism (RFLP), found to be effective. In future continuous efforts are required to devise new methods for rapid detection of these pathogens.
  M. Ismail Varol , Cafer Mart , Mehmet Ozaslan , Abdullah Bayram , Zubeyde Akan and Adile Ozdemir
  In this study, spider fauna of Hancağiz Dam (Gaziantep) was studied. In field trips, 817 specimens were collected; male and female examples were identified. As a result of determination, 18 families were recognized. Philodromidae, Lycosidae, Gnaphosidae and Thomisidae families were studied as detailed. Eight genus and 17 species were given as systematic categories.
  Safwan Moaket , Sibel Bayil Oguzkan , Ibrahim Halil Kilic , Bedrettin Selvi , Isik Didem Karagoz , Mehmet Erdem , Nese Erdogan , Huseyin Tekin and Mehmet Ozaslan
  Background and Objective: Iridaceae is a widespread family which include 92 genus and 6 of them are spreading in Turkey. This family includes wild plants whose endemic species have attractive flowers. Iris sari is a folk medicinal plant in Southeastern of Turkey. This study aimed to investigate the biological and bioactive properties of I. sari in Turkey. Materials and Methods: In this study, n-hexane, dicloromethane, methanol and water extracts from different parts (flower, leaf and rhizome) of I. sari were obtained by Soxhlet apparatus and their antioxidant, antibacterial and DNA protection activities were studied. Antioxidant activity, total antioxidant and oxidant levels were determined by using Relassay Diagnostics Kit (Antioxidant Kit, Turkey) and DPPH assay was used to determine antibacterial activity. Microdilution assay was conducted by using 9 different bacterial strains (S. aureus ATCC 25923, P. aeruginosa ATCC 27853, K. pneumoniae ATCC 700603, S. aureus ATCC 29213, E. coli ATCC 25322, E. coli ATCC 35218, E. coli ATCC 10799, E. coli ATCC 8739 and S. aureus ATCC 6538) according to CSL. To determine DNA protection activity, pBR322 plasmid DNA assay were used. Results: Results showed that water and methanol extracts of I. sari showed high antioxidant activities in both antioxidant methods. Although the highest antioxidant and antibacterial activities were found in root water extract, the most DNA protection effect was found in water and methanol extracts isolated from leaf and flower. Conclusion: It was concluded that the endemic and medicinal plant; I. sari contain active metabolites which are responsible for these antioxidant, antibacterial and DNA protection activities.
  Imene Benyettou , Omar Kharoubi , Nouria Hallal , Hadj Ali Benyettou , Kaddour Tair , Mansoria Belmokhtar , Abdelkader Aoues and Mehmet Ozaslan
  Background and Objective: Aluminium (Al) is a widely recognized neurotoxin that inhibits more than 200 biologically important functions inducing severe behavioral abnormalities, impaired cognitive functions and metabolic dysfunction. The present study was designed to investigate oxidative stress of aluminium induced toxicity in developing rat brain and enlarged to investigate the possible ameliorating role of omega-3 and omega-6 fatty acids with low and high ratio. Methodology: Aluminium was administered intraperitoneally (100 mg kg–1 b.wt., twice a week) to female adult rats. Postnatally (30 days), pups were given orally by gavage the low and high ratio of omega-6/omega-3 for 5 weeks. The antioxidative and protective properties of omega-6/omega-3 ratio against the effects of aluminium toxicity (Al) on behavior, redox status and leptin level was analysed by using the one way ANOVA test. Results: The results revealed that AlCl3 significantly increased (p<0.05) the level of Thiobarbituric Acid Reactive Substances (TBARS), Nitric oxide (NO), the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and Glutathione Peroxidase (GPx), while Glutathione Reductase (GR) was significantly decreased (p<0.05) in the cerebral cortex in intoxicated pup rats. Moreover, the leptin concentration was significantly increased (p<0.05) in cortex. On the other hand, the results exhibited that, omega-6/omega-3 when given in low or high dose were able to ameliorate the mentioned parameters approaching them to the normal ranges. Conclusion: It is concluded that aluminium may be attributed to induce disturbance of locomotor and stereotype behavior, anxiety, disturb antioxidant system and leptin level. Furthermore, the results suggested that the omega-3 and omega-6 could be able to antagonize Al neurotoxicity perhaps by its antioxidant properties.
  Rozhgar A. Khailany , Muhammad Safdar and Mehmet Ozaslan
  Background and Objective: Breast cancer is the type of cancer that most affects women around the world. It accounts for around 30% of all cancers. KRAS gene is mutually initiated in about 20% of every single vigorous cancer. However, the further development of clinically successful KRAS coordinated malignancy treatments was usually unsuccessful and KRAS mutant malignancies are among the most resistant drugs. KRAS gene variations usually occur in many adenocarcinomas such as; lung, pancreas, breast and colon. The role of oncogene KRAS in later periods of neoplastic development that is taken after the onset is still poorly understood. The aim of this study is to investigate mutation and mRNA expression level of KRAS in breast cancer patients by using DNA sequencing and semi-quantitative reverse transcriptase techniques. Materials and Methods: The study included 44 paired normal and tumor samples from patients grouped based on the types of breast cancer and the patients' clinical characteristics, including age and grade of tumors. Results: The KRAS expression on the level mRNA was significantly increased (up-regulated) in tumor samples compared to the control samples. However, a heterozygous mutation (G>A) (GGT/GAT) was identified in two patients in the KRAS gene. Conclusion: The up-regulated expression of KRAS on the level mRNA can be a risk factor for breast cancer development and the changed KRAS expression level can alter individual breast cancer sensitivity.
  Mehreen Arshad , Mehmet Ozaslan , Hafiz Khawar Ali , Muhammad Safdar , Yasmeen Junejo and Masroor E. Babar
  Background and Objective: Gold nanoparticles (AuNPs) widely had been used in the medicine and industries, but the safety of the gold NPs exposure remains unclear. The aim of the present study was to evaluate the toxic effects of thioacetamide (TAA) (300 μg kg1) and gold nanoparticles (AuNPs) (300 μg kg1) in the organs of mice. Materials and Methods: The mice were treated with fixed doses of gold nanoparticles and thioacetamide every day for 5 days. In the blood values of WBCs, RBCs, neutrophils and other blood components were changed as compared to normal values after the treatment in mice groups (1-3 and 4). Results: Results indicated that the thioacetamide caused the hepatic damage and caused down regulation of checkpoint gene p53 and also decreased the expression level of apoptotic caspase protein (Casp3, Casp8 and Casp9) which was measured by qRT-PCR. While the gold NPs upregulated the p53 gene which is responsible for the DNA repair and also known as the checkpoint of the cell cycle. The gold nanoparticles were activated and up-regulated the caspase-3, caspase-8 and caspase-9 and induced apoptosis. Conclusion: It was concluded that gold nanoparticles activated the apoptotic genes which had the ability to kill the cancer cell. However, further studies are recommended to have better insight.
  Mehmet Ozaslan , Muhamad Safdar , I. Halil Kilic and Rozhgar A. Khailany
  In view of the global COVID-19 pandemic, this study focuses on the most up-to-date epidemiology, transmission, clinical manifestations, effective management, prevention and maintaining social distancing worldwide. The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease was first reported from Wuhan, China, in December, 2019. Till now this pandemic had spread to 209 countries and territories around the world and 2 international conveyances with 1,455,519 confirmed cases, including 83,664 deaths, as of April 08, 2020, so the World Health Organization declared it as a Public Health Emergency of worldwide ( The main clinical manifestations are included fever, coughing, sore throat, fatigue, headache, diarrhea, hemoptysis, trouble breathing, blue lips or face, persistent pain or pressure in the chest, confusion and excessive drowsiness. Preventive measures such as; masks, frequent hand washing, staying at home, avoid public contact and quarantines are being recommended for reducing the transmission. To date, no specific antiviral treatment is proven yet. The countries with a high risk of infection, they need proper awareness and management for good protection.
  Mehmet Ozaslan
  Not Available
  Mehmet Ozaslan
  Not Available
  Mehmet Ozaslan
  Not available
  Mehmet Ozaslan and Sibel Bayil Oguzkan
  Plants provide the oxygen required for maintenance of human life. They are essential for human life in terms of food and health. Thousands of years ago, humans explored the therapeutic power of plants and preferred to benefit from them to live healthily. According to the data of the World Health Organization (WHO), the number of plants used for therapeutic purposes is around 20,000. Since the beginning of using plants for human health, the bioactivity characteristics of the plants have been studied in laboratories. There are various bioactive components in plants, the most important of which are secondary metabolites. It is very important how and by which methods the secondary metabolites of plants are characterized as well as their isolation, proper and effective performance of their extraction process and identification of their various biological activities that might be used in alternative medicine. This review examines the usability of supplementary medical support products after the identification of bioactive characteristics of plants by means of various biochemical and molecular biological methods.
  Mehmet Ozaslan , Berna Bas , Turkan Aytekin and Zeynep Sigirci
  Pepper growing are negatively affected due to the diseases caused by pepper viruses in Gaziantep. In order to avoid the damage of pepper viruses, survey was performed in Nurdagi and Islahiye districts of Gaziantep province located in southeastern Anatolia. The symptoms observed on pepper plants in yards were consisted of mosaic and curling, vein clearing, chlorotic and necrotic spot, fruit and leaf deformations. In October 2001, samples were collected and performed biological and serological assays. TMV and CMV were determined as responsible agent of these symptoms. GAP (Güney-Dogu Anadolu Projesi = Southeastern Anatolia Project) is one of the most important agricultural recovery projects of Turkey. One of GAP inclusion is Gaziantep become a leading producer of pepper in Turkey. Although damage by viruses is yet very below threshold level, an effective control strategies should be now argued to avoid from possible virus problems in longer term.
  Mehmet Ozaslan , Turkan Aytekin , Berna Bas , I. Halil Kilic , I. Didem Afacan and D.S. Dag
  Cucurbit growing is affected negatively due to diseases caused by cucurbit viruses. In order to prevent this damage cucurbit viruses were identified by serologically. Due to this study, it is usually difficult to give definitive diagnosis based on symptoms but occasionally symptoms; are curling, wrinkling, spot mosaics, yellowing, shape deformation on leaves, smaller leaves than normal, buff-colored mosaics, observed on younger leaves of cucurbits and stunting , distortion and fruit deformation on the plants. After this, samples collected and taken to laboratory to determine the virus which caused this symptoms and DAS -ELISA tests were performed to determine CMV (Cucumber mosaic virus), CABYV (Cucurbit aphid borne yellow mosaic virus), ZYMV (Zucchini yellow mosaic virus), ToMV (Tomato mosaic virus), PMMV (Pepper mild mottle virus), PXV (Potato X virus), PYV (Potato Y virus) on the samples collected during July-August in 2004. At the end of this test out of 56 samples, 10 were found to be infected with one or more virus. As a result of this study 20 samples were infected by CMV and 22 samples were infected by ZYMV and 3 samples were infected by PVY.
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