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Articles by Mehmet Kizilkaya
Total Records ( 3 ) for Mehmet Kizilkaya
  Omer S. Yildirim , Mehmet Kizilkaya , Ramazan Okutan and Fikrettin Sahin
  Structural changes and reactions of surrounding tissues after implantation could contribute loosening in orthopaedic surgery. The aim was to investigate the effect of orthopedic implants on fatty acid (FA) profile of surrounding tissues. New Zealand rabbits (n=40) were assigned randomly to one of four commonly used orthopaedic implants (ceramic, titanium, polyethylene and stainless steel) and sham. One month after surgical intervention, the pseudomembranes developed in response to applications were harvested for FA and histopathology. The cellular FA profile was determined using gas chromatography. Fibrotic tissues developed in response to all implants. Fatty acid profile of cells surrounding implanted tissues was different from that of periosteoum (sham group). C was the most prevalent FA in all samples. C was absent in the stainless steel 16:0 16:1 group, whereas C was present in only in the control and ceramic groups. Fatty acid profile of the 17:1 polyethylene group was similiar to that of the ceramic group. More significantly, tissues facing titanium and stainless steel contained neutophil infiltration, lympho-plasmocytes at the center of fibrotic connective tissues, macprophages and gigantic cells. As compared with ceramics and polyethylene, metallic materials may prone to greater risk for loosing due to remarkeable structural changes in surrounding tissues facing implants.
  Armagan Hayirli , Fikrullah Kisa , Zafer Okumu and Mehmet Kizilkaya
  Epidemiological and clinical trials concerning cancers have received enormous attention and financial support because cancers continue to be the most death leading health problem in developed and developing countries. However, it is a challenge to investigate the role of nutrition in prevention of cancers due to involvement of multifactors. A group of organic micronutrients including ascorbic acid, retinoic acid, pyridoxine, methionine, folate, cobalamin, and choline are known as methyl donors and shown to inhibit carcinogenesis. Mechanisms by which these substances directly and indirectly inhibit carcinogenesis include formations of intermediary metabolites that inhibit nucleic acid synthesis, prevent tissues from autooxidative damages, and enhance regenerating process of tissues. In this mini-review, current information on the roles of folate, cobalamin, and choline in inhibition of carcinogenesis were presented.
  C.R. Kayaoglu , Sedat Binler , Mehmet Kizilkaya and Goksin Sengul
  This study aims to investigate the therapeutic effect of progesterone on experimental peripheral nerve injury. Methods: A total of 20 male Albino rats weighing 250-300 g were anaesthetized and subjected to sciatic nerve injury model. Rats were then seperated into two groups; one group was treated with progesterone and the other with saline for five time up to 21 days after injury. Both groups were evaluated fuctionally for 21 days and then killed. Sciatic nerves were examined histopathologically. There was no statistically significant difference between these two groups for up to 4 days. But evaluations after 4th day revealed a better improvement in progesterone treatment group. Our data indicate that progesterone has a beneficial effect in peripheral nerve injury.
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